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周晓辉
教授
zhouxh@sustech.edu.cn

个人简介

周晓辉,南方科技大学教授、博士生导师,入选国家高层次人才计划。2008年获华盛顿州立大学微生物学博士,曾担任美国康涅狄格大学病原生物学系终身教授,疫苗研究中心研究员(Principal Investigator)。已发表论文80余篇,其中通讯作者论文30余篇(包括PNAS,EMBO J,Nature Communications,Biomaterials, PLoS Pathogens等国际一流期刊)。曾主持多个美国NIH R01项目及美国农业部项目,获总额300余万美元资助,授权多个国内国际专利。现任微生物学领域知名期刊Microbiological Research 主编(Editor-in-Chief),长期受邀担任包括EMBO J, eLife, mBio, Biomaterials等多个国际一流期刊审稿专家。


研究方向

1.     病原微生物与宿主互作及致病的分子机制

2.     感染性疾病疫苗的开发与研究

3.     抗生素耐药机制及新型抗感染药物的开发


工作经历

2022 – 至今: 南方科技大学                         教授

2013 – 2022:美国康涅狄格大学病原生物系 助理教授、副教授、终身教授、研究员 (PI)    

2010 – 2013:哈佛大学医学院/HHMI          研究助理  

2008 – 2010:美国华盛顿州立大学              博士后   


代表性论文(#共同一作,*通讯作者)

1.  Huang M, Wang Z, Yao L, Zhang L, Gou X, Mo H, Li H, Hu L, Zhou X*. Ferric chloride induces ferroptosis in Pseudomonas aeruginosa and heals wound infection in a mouse model. Int J Antimicrob Agents. 2023, 61(5):106794.

2.  Wang Z, Li H, Zhou W, Lee J, Liu Z, An Z, Xu D, Mo H, Hu L, Zhou X*. Ferrous sulfate-loaded hydrogel cures Staphylococcus aureus infection via facilitating a ferroptosis-like bacterial cell death in a mouse keratitis model. Biomaterials 2022, 290:121842.

3. Hu M, Zhang Y, Gu D, Chen X, Waldor MK and Zhou X*. Nucleolar c-Myc recruitment by a Vibrio T3SS effector promotes host cell proliferation and bacterial virulence. The EMBO J. 2021, 15;40(2): e105699.

4. Gu D, Zhang Y, Wang Q and Zhou X*. S-nitrosylation mediated activation of a histidine kinase represses T3SS1 gene expression and promotes virulence of an enteric pathogen. Nat. Commun. 2020, 11:5777.

5. Hu M, Zhang H, Gu D, Ma Y and Zhou X*. Identification of the first tail tubular proteins receptor that mediates phage adsorption to a marine pathogen Vibrio parahaemolyticus. Emerging Microbes & Infections. 2020. 9:855-867.

6. Gu D, Yang M, Zhang Y, Zhou X*, and Wang*. A σE-mediated temperature gauge controls a switch from LuxR-mediated virulence gene expression to thermal stress adaptation in Vibrio alginolyticus. PLoS Pathogens. 2016, 2; 12(6): e1005645.

7. Li L, Wang, Zhang H, Kahn K and Zhou X*. A sensor histidine kinase is a beta-lactam receptor and induces resistance to beta-lactam. PNAS. 2016,113 (6):1648-1653. (Highlighted by Nature Review Microbiology: https://www.nature.com/articles/nrmicro.2016.27)

8. Zhou X, Gewurz BE, Ritchie JM, Takasaki K, Davis BM, and Waldor MK. A Vibrio parahaemolyticus type III effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Reports. 2013 30:1690-702.

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