个人简介：

赵燕，生命科学学院神经生物学系副教授，博士生导师，基金委优秀青年科学基金获得者，于2020年11月全职回国加入南方科技大学生命科学学院。赵燕本科和博士均毕业于北京大学医学部，并先后在中国科学院生物物理所和美国马萨诸塞大学医学院进行博士后工作，进行细胞自噬的分子机制和生理功能研究，以第一作者和/或通讯作者身份在Molecular Cell、Current Biology、JCB、Autophagy、Cell reports等国际顶尖学术期刊发表论文多篇。

研究领域：

自噬是细胞内重要的降解机制，对于维持细胞稳态至关重要。在体内，自噬保障了机体各器官的正常生理功能，自噬异常导致多种人类疾病的发生发展。课题组未来的研究方向主要集中在研究多细胞特有自噬蛋白在自噬过程中的分子机制和体内功能，具体包括以下方向：

1. 研究自噬小体形成过程中，内质网与自噬前体结构的相互作用的调控和功能

2. 研究神经细胞自噬的特有分子机制，寻找神经退行性疾病的潜在治疗靶点

3. 研究内质网与细胞内其他细胞器相互作用的分子组成、调节机制和生理功能

4. 研究冠状病毒转录复制过程中双层膜囊泡（DMV）的形成机制

代表文章：

1.Li, M., Hou, Y., Zhou, Y., Yang, Z., Zhao, H., Jian, T., Yu, Q., Zeng, F., Liu, X., Zhang, Z., and Zhao, Y.G. (2024). LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation. J Cell Biol 223 e202309140.

2.Ji, M., Li, M., Sun, L., Zhao, H., Li, Y., Zhou, L., Yang, Z., Zhao, X., Qu, W., Xue, H., Zheng, Z., Li, Y., Deng, H., and Zhao, Y.G. (2022) VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection. J Cell Biol 221, e202112081.

3. Ji, C., Zhao, H., Zhang, H., and Zhao, Y.G. (2021) β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells. Curr Biol 31, 1666-1677.

4. Ji, C., Zhao, H., Li, D., Sun, H., Hao, J., Chen, R., Wang, X., Zhang, H., and Zhao, Y.G. (2020) Role of Wdr45b in maintaining neural autophagy and cognitive function. Autophagy 16, 615-625.

5. Li, D., Zhao, Y.G.*, Li, D., Zhao, H., Huang, J., Miao, G., Feng, D., Liu, P., Li, D., and Zhang, H. (2019) The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation. Cell Rep 27, 343-358. (*Zhao, Y.G. as co-first author)

6. Zhao, Y.G., Liu, N., Miao, G., Chen, Y., Zhao, H., and Zhang, H. (2018) The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis. Curr Biol 28, 1234-1245.

7. Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H. (2017) The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation. Mol Cell 67, 974-989.

8. Zhao, Y.G., Sun, L., Miao, G.Y., Ji, C.C., Zhao, H.Y., Sun, H.Y., Miao, L., Yoshii, S.R., Mizushima, N., Wang X.Q., and Zhang, H. (2015) The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis. Autophagy 11, 881-890.

9. Zhao, Y.G.*, Zhao, H.Y., Sun, H.Y., and Zhang, H. (2013) Role of Epg5 in selective neurodegeneration and Vici syndrome. Autophagy 9, 1185-1189. (*Zhao, Y.G. as first author and co-corresponding author)

10. Zhao, H.Y., Zhao, Y.G.*, Wang, X.W., Xu, L.J., Miao, L., Feng, D., Chen, Q., Kovács, A.L. Fan, D.S., and Zhang, H. (2013) Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol 200, 731-741. (*Zhao, Y.G. as co-first author and co-corresponding author)

11. Zhao, Y.G., Zhao, H.Y., Miao, L., Wang, L., Sun, F., and Zhang, H. (2012) The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem 287, 42053-42063.