个人简介：

冯宇亮，南方科技大学药理学系研究员、副教授，博士生导师。牛津大学分子与细胞医学博士。致力于利用崭新的三维基因组/表观遗传组学技术揭示人类疾病特别是心血管病和肿瘤发生的转录调控机制，参与了NIH ENCODE (Encyclopedia of DNA Elements)、4DN (4D Nucleome) 、欧洲BLUEPRINT等大型三维基因组及表观遗传组学项目。已在国际主流学术期刊，如Circulation、Gastroenterology、Advanced Genetics、Nature Communications、Nucleic Acids Research、Science Advances、Journal of Medical Virology、Theranostics、Basic Research in Cardiology、Protein&Cell、Stem Cells等发表文章30多篇。目前为Nucleic Acids Research、Advanced Science、Acta Pharmaceutica Sinica B (APSB)、Redox Biology、Aging and Disease、Pharmacological Research、iScience等20多个SCI期刊审稿人；eGastroenterology(BMJ期刊)青年编委及Cells、Frontiers in Pharmacology、Frontiers in Immunology、Frontiers in Bioengineering and Biotechnology及Frontiers in Molecular Biosciences等5个期刊客座编辑。

教育背景：

2019.10-2022.11   英国牛津大学，哲学博士，分子与细胞医学

2008.09-2014.06   南方医科大学，医学博士，药理学

2003.09-2008.06   中山大学，医学学士，预防医学

工作经历：

2022.11-至今    南方科技大学药理学系，副教授

2017.03-2019.07   美国杰克逊实验室，基因组科学部，博士后

2014.10-2016.06   荷兰奈梅亨大学，分子生物学系，博士后

2010.01-2014.02   美国辛辛那提大学，病理学系，博士后

获奖情况及荣誉：

获国家级人才头衔

广东省杰青

获深圳市人才头衔

Gordon Research Conference受邀报告人（2023）

ISHR Richard J Bing Young Investigator Award Finalist（2022）

牛津大学Botnar Research Centre Best Poster Award (2021)

牛津大学Clarendon Fund (Clarendon Scholar) (2019-2022)

Winkler Oxford Award in Medicine or Psychology（2019）

ISHR 全球会议Travel Award (2010 日本、2013美国、2016阿根廷)

ISHR中国分会青年优秀论文一等奖（2012、2014）

研究领域：

心血管病和肿瘤发生的三维基因组与表观遗传调控

学术任职：

中国病理生理学会心血管专业委员会秘书（2016-2018）

中国病理生理学会心血管专业委员会秘书青年委员会会员（2016-2018）

国际心脏研究会(ISHR)中国转化医学工作委员会委员（2016- ）

美国心脏协会(AHA)会员

国际心脏研究会(ISHR)会员

发表论文 (#共同第一作者; *共同通讯作者; ‡ Lead Contact)：

1. Jun Qiao, Qian Wang, Yuhui Zhao, Minjing Chang, Liuyang Cai, Feng Liu, Kaixin Yao, Leilei Zheng, Ning Tan, Pengcheng He, Anil G. Jegga, Siim Pauklin*, Lei Jiang*, Yining Yang*, Yuliang Feng*. Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysis. medRxiv.  2024.05.20.24307614; doi: https://doi.org/10.1101/2024.05.20.24307614

2. Zhuo Z, Guo K, Luo Y, Yang Q, Wu H, Zeng R, Jiang R, Li J, Wei R, Lian Q*, Sha W*, Feng Y*, Chen H*. Targeted modulation of intestinal epithelial regeneration and immune response in ulcerative colitis using dual-targeting bilirubin nanoparticles. Theranostics. 2024 Jan 1;14(2):528-546. doi: 10.7150/thno.87739. PMID: 38169633; PMCID: PMC10758062.

3. Feng Y＃, Cai L＃, Pook M＃, Liu F, Chang CH, Mouti MA, Nibhani R, Militi S, Dunford J, Philpott M, Fan Y, Fan GC, Liu Q, Qi J, Wang C, Hong W, Morgan H, Wang M, Sadayappan S, Jegga AG, Oppermann U, Wang Y*, Huang W*, Jiang L*, Pauklin S*. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. Gastroenterology. 2023 Sep 20:S0016-5085(23)05012-6. doi: 10.1053/j.gastro.2023.09.021.

4. Jun Qiao, Liuyang Cai, Minjing Chang, Can Wang, Rong Zhao, Shan Song, Ning Tan, Pengcheng He*, Siim Pauklin*, Lei Jiang*, Yuliang Feng*. Shared Genetic Architecture Contributes to Risk of Major Cardiovascular Diseases, 18 September 2023, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-3261702/v1]

5. Xie J＃, Feng Y＃, Newby D, Zheng B, Feng Q, Prats-Uribe A, Li C, Wareham NJ, Paredes R, Prieto-Alhambra D*. Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection. Nat Commun. 2023 Aug 3;14(1):4659. doi: 10.1038/s41467-023-40310-0.

6. Meng M, Wu Y, Sha W, Zeng R, Luo D, Jiang R, Wu H, Zhuo Z, Yang Q, Li J, Leung FW*, Duan C*, Feng Y*, Chen H*. Associations of habitual glucosamine use with SARS-CoV-2 infection and hospital admission and death with COVID-19: Evidence from a large population based cohort study. J Med Virol. 2023 Apr;95(4):e28720. doi: 10.1002/jmv.28720. PMID: 37185863.

7. Madrigal P, Deng S, Feng Y, Militi S, Goh KJ, Nibhani R, Grandy R, Osnato A, Ortmann D, Brown S, Pauklin S*. Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation. Nat Commun. 2023 Jan 25;14(1):405.

8. Feng Y*＃, Cai L＃, Hong W＃, Zhang C＃, Tan N, Wang M, Wang C, Liu F, Wang X, Ma J, Gao C, Kumar N, Mo Y, Geng Q, Luo C, Lin Y, Chen H, Wang S, Watson M, Jegga A, Pedersen R, Fu J, Wang Z, Fan G, Sadayappan S, Wang Y, Pauklin S*, Huang F*, Huang W*, Jiang L*. Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation. 2022 May 31;145(22):1663-1683. doi: 10.1161/CIRCULATIONAHA.121.055781.

9. Feng Y＃, Wang P＃, Cai L＃, Zhan M＃, He F, Wang J, Li Y, Gega E, Li S, Zhang W, Zhao W, Xin Y, He X, Chen X*, Ruan Y, Lu L*.  3D-Epigenomic Regulation of Gene Transcription in Hepatocellular Carcinoma Cells. Adv Genet. 2022 Jun 29;3(4):2100010. doi: 10.1002/ggn2.202100010. eCollection 2022 Dec.

10. Deng S, Feng Y, Pauklin S*. 3D chromatin architecture and transcription regulation in cancer. J Hematol Oncol. 2022 May 4;15(1):49.

11. Wen Z＃, He K＃, Zhan M＃, Li Y, Liu F, He X, Wei Y, Zhao W, Zhang Y, Xue Y, Xia Y, Lian Y, Xia Z, Xin Y, Wu Y, Duan X, Xiao J, Shen F*, Feng Y*, Xiang G*, Lu L*. EZH2 and JARID2 shift their binding profiles on RNAs and DNAs between hepatocellular carcinoma and normal liver cells. Front Oncol. 2022 Dec 9;12:904633.

12. Feng Y＃, Huang W＃, Paul C, Liu X, Sadayappan S, Wang Y*, Pauklin S*. Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases. Basic Res Cardiol. 2021 Aug 14;116(1):49.

13. Lin Z, Ding Q, Li X, Feng Y, He H, Huang C, Zhu Y*. Targeting Epigenetic Mechanisms in Vascular Aging. Front Cardiovasc Med. 2022 Jan 4;8:806988.

14. He K＃, Feng Y＃, An S＃, Liu F, Xiang G*. Integrative epigenomic profiling reveal AP-1 is a key regulator in intrahepatic cholangiocarcinoma. Genomics. 2021 Dec 20;114(1):241-252.

15. Wang P, Feng Y, Zhu K, Chai H, Chang YT, Liu X, Shen C, Gega E, Li B, Kim M, Ruan X, Ruan Y*. In Situ Chromatin Interaction Analysis Using Paired‐End Tag Sequencing. Curr Protoc. 2021 Aug;1(8):e174.

16. Jie M, Feng T, Huang W, Zhang M, Feng Y*＃, Jiang H*, Wen Z*. Subcellular Localization of miRNAs and Implications in Cellular Homeostasis. Genes (Basel). 2021 Jun 2;12(6):856.  

17. Wen Z*, Feng Y, Jiang L. Phosphodiesterase-5 inhibitors in Men with Stable Coronary Artery Disease. J Am Coll Cardiol. 2021 Jul 20;78(3):294-295.

18. Feng Y, Mouti M and Pauklin S*. PAF1 regulates the stemness of pancreatic cancer stem cells. Gastroenterology. 2021 May;160(6):2224-2225.

19. Wen Z*＃, Feng Y＃ and Yan X. Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B. J Hepatol. 2021;74:245-246.

20. Feng Y, Liu X and Pauklin S*. 3D chromatin architecture and epigenetic regulation in cancer stem cells. Protein Cell. 2021 Jun;12(6):440-454.

21. Lee B, Wang J, Cai L, Kim M, Namburi S, Tjong H, Feng Y, Wang P, Tang Z, Abbas A, Wei CL*, Ruan Y* and Li S*. ChIA-PIPE: A fully automated pipeline for comprehensive ChIA-PET data analysis and visualization. Sci Adv. 2020;6:eaay2078.

22. French R＃, Feng Y＃ and Pauklin S*. Targeting TGFbeta Signalling in Cancer: Toward Context-Specific Strategies. Trends Cancer. 2020;6:538-540.

23. Feng Y and Pauklin S*. Two Sides of the Same Coin: The Roles of Transforming Growth Factor-beta in Colorectal Carcinogenesis. Gastroenterology. 2020;159:397-398.

24. Feng Y and Pauklin S*. Demystifying Cancer Etiology via 3D Genome Mapping. Trends Genet. 2020;36:634-637.

25. Feng Y and Pauklin S*. Revisiting 3D chromatin architecture in cancer development and progression. Nucleic Acids Res. 2020;48:10632-10647.

26. Huang W＃, Liang J＃, Feng Y＃, Jia Z, Jiang L, Cai W, Paul C, Gu JG, Stambrook PJ, Millard RW, Zhu XL, Zhu P* and Wang Y*. Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential. Exp Cell Res. 2018;371:20-30.

27. Huang W＃, Feng Y＃, Liang J＃, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY* and Wang Y*. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018;9:700.

28. Meng W, Tai Y, Zhao H, Fu B, Zhang T, Liu W, Li H, Yang Y, Zhang Q, Feng Y*and Chen G*. Downregulation of miR-33a-5p in Hepatocellular Carcinoma: A Possible Mechanism for Chemotherapy Resistance. Med Sci Monit. 2017;23:1295-1304.

29. Jiang XY, Feng YL, Ye LT, Li XH, Feng J, Zhang MZ, Shelat HS, Wassler M, Li Y, Geng YJ* and Yu XY*. Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. Stem Cell Reports. 2017;8:290-304.

30. Li XH, Li Q, Jiang L, Deng C, Liu Z, Fu Y, Zhang M, Tan H, Feng Y, Shan Z, Wang J* and Yu XY*. Generation of Functional Human Cardiac Progenitor Cells by High-Efficiency Protein Transduction. Stem Cells Transl Med. 2015;4:1415-24.

31. Cai WF, Kang K, Huang W, Liang JL, Feng YL, Liu GS, Chang DH, Wen ZL, Paul C, Xu M, Millard RW and Wang Y*. CXCR4 attenuates cardiomyocytes mitochondrial dysfunction to resist ischaemia-reperfusion injury. J Cell Mol Med. 2015;19:1825-35.

32. Wen Z, Huang W, Feng Y, Cai W, Wang Y, Wang X, Liang J, Wani M, Chen J, Zhu P, Chen JM, Millard RW, Fan GC and Wang Y*. MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PLoS One. 2014;9:e104666.

33. Feng Y, Huang W, Wani M, Yu X* and Ashraf M*. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One. 2014;9:e88685. (ESI高被引论文)

34. Feng Y＃, Huang W＃, Meng W, Jegga AG, Wang Y, Cai W, Kim HW, Pasha Z, Wen Z, Rao F, Modi RM, Yu X* and Ashraf M*. Heat shock improves Sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: a critical role for HSF1/miR-34a/HSP70 pathway. Stem Cells. 2014;32:462-72.

35. Wang L, Pasha Z, Wang S, Li N, Feng Y, Lu G, Millard RW and Ashraf M*. Protein kinase G1 alpha overexpression increases stem cell survival and cardiac function after myocardial infarction. PLoS One. 2013;8:e60087.

36. Feng Y, Yu XY and Wang Y. Recent concepts for the roles of progenitor/stem cell niche in heart repair. Am J Cardiovasc Dis. 2012;2:75-83.

37. Feng Y, Wang Y, Cao N, Yang H and Wang Y*. Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med. 2012;1:65-77.

38. Feng Y and Yu X*. Cardinal roles of miRNA in cardiac development and disease. Sci China Life Sci. 2011;54:1113-20.

39. Haider H*, Mustafa A, Feng Y and Ashraf M. Genetic modification of stem cells for improved therapy of the infarcted myocardium. Mol Pharm. 2011;8:1446-57.