个人简介：

苏杨博士，南方科技大学生命科学学院研究助理教授，江苏海洋大学学士，南京师范大学生物学博士，上海交通大学和南方科技大学博士后。主要研究磷酸肌醇的功能和蛋白质稳态的代谢调控。获国家自然科学基金青年项目、广东省自然科学基金面上项目、深圳市基础研究面上项目资助。以第一作者或共第一作者在Molecular Cell，mbio，FEBS Journal等杂志上发表研究论文多篇。入选深圳市高层次人才计划。

研究领域：

Culling-ING ligase(CRL)泛素连接酶是最大的E3泛素连接酶群体，介导体内总泛素化的20%。CRLs需要被拟素化修饰激活才能行使功能，受去拟素酶CSN复合体抑制。我们研究CRL拟素化的代谢分子调控路径，包括多磷酸肌醇小分子和营养。

工作经历：

2021.11 - 至今，南方科技大学，神经生物学系，研究助理教授

2018.12 - 2021.7，南方科技大学，神经生物学系，博士后，合作导师：饶枫副教授

2016.07 - 2018.09，上海交通大学医学院，微生物与免疫学学系，博士后，合作导师：姚玉峰教授

学习经历：

2011.09 - 2016.06，南京师范大学，生命科学学院，博士，导师：黄鹰教授

2007.09 - 2011.06，江苏海洋大学，海洋学院，学士

代表文章：

(1) Yang Su^(#), Yifan Luo^(#), Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie,  Keren Zhang, Qiuyu Fu, Hao Chen, Niu Huang, Yan Ren, Mingxuan Wu, Billy Kwok Chong Chow, Xing Chen, Wenfei Jin, Fengchao Wang*, Li Zhao*, Feng Rao*, Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis, Molecular Cell, 2023 Jun 6;83(13):2316-2331. 

(2) Yang Su^(#), Jianhui Li^(#), Wenting Zhang^(#) Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu*, Jie Lu*, Yu-Feng Yao*, Methylation of PhoP by CheR regulates Salmonella virulence, mBio. 2021 Sep 21; e0209921. doi: 10.1128/mBio.02099-21. 

(3) Su Y, Yang Y, Huang Y^(*), Loss of ppr3, ppr4, ppr6 or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe, FEBS J, 2017, 284(2): 324-337.

(4) Su Y^(#), Chen C^(#), Huang L^(#), Yan J, Huang Y^(*), Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance, PloS One, 2015, 10(12): e0143888.

(5) Zhao Q^(#), Su Y^(#), Wang Z^(#), Chen C, Wu T, Huang Y^(*), Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe, Bmc Evol Biol, 2014, 14: 86.

(6) Su Y, Chen J, Huang Y^(*), Disruption of ppr3, ppr4, ppr6, or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe, FEMS Microbiol Lett, 2018 Aug 1;365(16).

(7) Ren J^(#), Sang Y^(#), Qin R, Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF^(*), Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation, Emerg Microbes Infect, 2019;8(1):55-69. 

(8) Rao F^(*), Lin H, Su Y, Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and NewPhysiologic Players, Adv Exp Med Biol, 2020;1217:47-60.

(9) Lin H^(#), Zhang X^(#), Liu L^(#), Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T*, Rao F*, Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome, Proceedings of the National Academy of Sciences, 2020 Feb 25;117(8):4117-4124.

(10) Xiaozhe Zhang, Shaodong Shi, Yang Su, Xiaoli Yang, Sining He, Jing Wu, Jian Zhang, Feng Rao*, Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat, J Biol Chem, 2020 Jun 3;jbc.RA120.014375. 

(11) Jianhui Li^(#), Shuting Liu^(#), Yang Su, Jie Ren, Yu Sang, Jinjing Ni, Jie Lu, Yu-Feng Yao*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence, Infect Immun, 2020 Dec 14;IAI.00588-20. 

(12) Hong Lin^(#), Yuan Yan^(#), Yifan Luo^(#), Wing Yan So^(#), Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang & Feng Rao*, IP6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion against hyperinsulinemia, Nature Communications, 2021 Apr 28;12(1):2461.

(13) Yifan Luo, Yang Su & Feng Rao*, Role of NEDD8 and neddylation dynamics in DNA damage response, Genome Instability & Disease, 2021, volume 2, pages139–149.