师资
吴长锋教授，南科大生物医学工程系教学副主任。1998年本科毕业于齐鲁工业大学，2004年获中科院长春光机所物理学博士学位，2008年获得美国Clemson大学化学博士学位，随后赴西雅图华盛顿大学从事博士后研究。回国工作后，先后获得国家自然科学基金优秀青年项目、国家自然科学基金重点项目、国家重点研发计划、和深圳市孔雀团队项目资助，主要研究方向为光学分子探针和生物成像技术。发表SCI 论文150余篇，引用12000多次，连续三年入选“爱思唯尔”中国高被引学者榜单。先后开设《生物医学光学》、《生物医学光学实验》、《生物医学工程概论》、《研究生综合培训》、《高级显微学》等课程。
实验室主页：http://wulab.bme.sustech.edu.cn/
研究方向：
1）荧光调控及超分辨成像（Fluorescence modulation and super-resolution imaging）
2）可穿戴生物传感系统（Wearable biosensor and monitoring system）
3）近红外荧光及脑组织成像（NIR fluorescence and brain imaging）
4）合成生物学与免疫成像（Synthetic biology and immunoimaging）
5）非线性光学成像（Nonlinear optical imaging）
教育背景
1994-1998 齐鲁工业大学材料科学与工程学院 本科
1998-2001 吉林大学材料科学与工程学院 硕士
2001-2004 中科院长春光机与物理研究所 凝聚态物理博士
2005-2008 美国Clemson大学化学系 物理化学博士
工作经历
2004-2005 美国Clemson大学物理系 博士后
2008-2011 美国华盛顿大学化学系 博士后
2011-2016 吉林大学电子科学与工程学院 教授
2016年-至今 南方科技大学生物医学工程系 教授
项目负责人
2023--2027 国家自然科学基金重点项目 “活体深层脑组织近红外二区超分辨成像研究”
2020--2025 国家重点研发计划课题 “恶性消化系肿瘤特异性分子探针的精确核素标记与方法学研究”
2019--2024 深圳市孔雀团队项目“脑瘤靶向探针及诊疗技术”
2018--2021 国家自然科学基金面上项目 “聚合物量子点植入型葡萄糖传感器及相关微光学系统的研究”
2014--2018 国家自然科学基金重点项目“开关/闪烁可控聚合物量子点的设计制备及纳米分辨动态光学成像研究”
2013--2015 国家自然科学优秀青年基金项目“生物医学光子学”
发表论文
1.Zhang, Z.; Fang, X.; Liu, Z.; Liu, H.; Chen, D.; He, S.; Zheng, J.; Yang, B.; Qin, W.; Zhang, X.; Wu, C.*, Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging. Angewandte Chemie International Edition 2020, 59, 3691-3698.
2.Lei, C.; Chen, D.; Jiang, Y.; Zhang, J.; Yu, J.; DuFort, C.C.; Hingorani, S.R.; Zhang, X.; Wu, C.*; Chiu, D.T.*, A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features. Angewandte Chemie International Edition 2019, 58(21), 7008-7012.
3.Zhang, B.; Wang, F.; Zhou, H.; Gao, D.; Yuan, Z.; Wu, C.*; Zhang, X.*, Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy. Angewandet Chemie- International Edition 2019, 58(9), 2744-2748.
4.Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers. Laser & Photonics Reviews 2019, 13(2), 1800326.
5.Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone, ACS Nano 2018, 12 (6), 5176–5184
6.Chen, H.; Fang, X.; Jin, Y.; Hu, X.; Yin, M.; Men, X.; Chen, N.; Fan, C.; Chiu, D. T.; Wan Y.*; Wu, C.*, Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery. Small 2018, 14(21), 1800239.
7.Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters 2017, 17 (7), 4323-4329.
8.Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots. ACS Nano 2017, 11 (8), 8084-8091.
9.Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy. Advanced Materials 2017, 29 (5), 1604859.
10.Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications. Chemical Science 2017, 8 (5), 3390-3398.
11.Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*; Biomaterials. 2017, 144, 42-52.
12.Chen, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics 2017, 7(7), 1820-1834.
13.Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 10 (7), 6769-6781.
14.Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine. Angewandet Chemie- International Edition 2013, 52 (11), 3086-3109.
15.Yu, J.; Wu, C.; Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging. Advanced Materials 2012, 24 (26), 3498-3504.
16.Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting. Angewandet Chemie- International Edition 2011, 50 (15), 3430-3434.
17.Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting. Journal of American Chemical Society 2010, 132 (43), 15410-15417.
18.Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angewandet Chemie- International Edition 2010, 49 (49), 9436-9440.
19.Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angewandet Chemie- International Edition 2009, 48 (15), 2741-2745.
20.Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J., Nanoscale 3D tracking with conjugated polymer nanoparticles. Journal of American Chemical Society 2009, 131(51), 18410-18414.
21.Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles. Journal of Physical Chemistry C 2008, 112(6), 1772-1781.
22.Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging. ACS Nano 2008, 2 (11), 2415-2423.
23.Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. Journal of American Chemical Society 2007, 129 (43), 12904-12905.
24.Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles. Journal of Physical Chemistry B 2006, 110(29), 14148-14154.
25.Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles. Langmuir 2006, 22(7), 2956-2960.