个人简介：

朱琼花，南方科技大学研究助理教授。2016年博士毕业于德国洪堡大学，同年进入德国亥姆霍兹联合会马克斯-德尔布吕克分子医学中心从事博士后研究，2019年加入南方科技大学并工作至今。现主要基于多种组学技术、高通量筛选技术研究肿瘤演化、肿瘤异质性及基因转录调控。

研究领域：

1. 肿瘤演化和肿瘤异质性；

2. 基因转录调控；

3. 单细胞组学；

工作经历：

2019 - 至今 南方科技大学

2016 - 2019 德国亥姆霍兹联合会马克斯-德尔布吕克分子医学中心

代表文章： 

1. Zhu Q#*, Zhao X#, Zhang Y#, Li Y#, Liu S#, Han J, Sun Z, Wang C, Deng D, Wang S, Tang Y, Huang Y, Jiang S, Tian C, Chen X, Yuan Y, Li Z, Yang T, Lai T, Liu Y, Yang W, Zou X, Zhang M, Cui H, Liu C, Jin X, Hu Y, Chen A, Xu X, Li G, Hou Y, Liu L*, Liu S*, Fang L*, Chen W*, Wu L*. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nat Commun. 2023 Dec 9;14(1):8170. doi: 10.1038/s41467-023-43991-9. PMID: 38071219; PMCID: PMC10710513.

2.  Yi H, He Y, Zhu Q, Fang L. RUNX Proteins as Epigenetic Modulators in Cancer. Cells. 2022 Nov 20;11(22):3687.

3. Cui H, Yi H, Bao H, Tan Y, Tian C, Shi X, Gan D, Zhang B, Liang W, Chen R, Zhu Q, Fang L, Gao X, Huang H, Tian R, Sperling SR, Hu Y, Chen W. The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling. Nat Commun. 2022 Aug 9;13(1):4680.

4. Zhao T, Sun Y, Zhu Q, Li X, Baghaee M, Wang Y, Yuan H*. A contraction-reaction-diffusion model for circular pattern formation in embryogenesis. Journal of the Mechanics and Physics of Solids. 2021. 157.

5. Fang L#*, Li G#, Sun Z, Zhu Q, Cui H, Li Y, Zhang J, Liang W, Wei W, Hu Y, Chen W*. CASB: A concanavalin A-based sample barcoding strategy for single-cell sequencing. Mol Syst Biol, 2021 Apr;17(4):e10060.

6. Yi H#, Li G#, Long Y, Liang W, Cui H, Zhang B, Tan Y, Li Y, Shen L, Deng D, Tang Y, Mao, C, Tian S, Cai Y, Zhu Q, Hu Y*, Chen W*, Fang L*. Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene, 2020. 39(28): p. 5152-5164.

7. Fang L#*, Wang W#, Li G#, Zhang L, Li J, Gan D, Yang J, Tang Y, Ding Z, Zhang M, Zhang W, Deng D, Song Z, Zhu Q, Cui H, Hu Y, Chen W*. CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators. Mol Syst Biol. 2020 Nov;16(11):e10025.

8. Praktiknjo S#,*, Obermayer B#, Zhu Q#, Fang L, Liu H, Quinn H, Stoeckius M, Kocks C, Birchmeier W*, Rajewsky N*. Tracing tumorigenesis in a solid tumor model at single-cell resolution. Nat Commun. 2020 Feb 20;11(1):991.

9.  Zhu Q#, Fang L#, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunaga-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W. The Wnt-driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell reports. 2019 Jan 26: 415–428.

10. Ma Y#, Peng Y#, Zhu Q#, Gao A#, Chao B, He Q, Li J, Hu Y, Zhou Y. CHOP activator LGH00168 induces necroptosis via reactive oxygen species-induced ER stress and NF-κB inhibition in A549 lung cancer cells. Acta Pharmacologica Sinica. 2016 Sep;37(10):1381-1390.

11. Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W. A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Research. 2016 Feb 15;76(4):891-901.

12. Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W. Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J. 2013 Jul 17;32(14):1977-89.