个人简介：

谭鹏，南方科技大学医学院生化系助理教授、副研究员、博士生导师。此前于麻省理工学院-哈佛大学Broad Institute 从事博士后研究，师从著名计算生物学家Aviv Regev 和肠病专家Ramnik Xavier。博士阶段在康奈尔医学院附属休斯顿卫理公会医院Rong-Fu Wang 实验室从事肿瘤免疫学研究。致力于利用Proximity labeling和蛋白质组学、光遗传学、新型单细胞空间多组学、大规模体内Perturb-seq等技术和小鼠模型研究炎症相关疾病的致病机理、肿瘤免疫逃逸机制、神经免疫互作和肠脑轴。作为国际学术组织Human Cell Atlas和Food Allergy Science Initiative成员，参与粘膜神经与食物过敏相关研究。曾获美国克罗恩病与结肠炎基金会CCFA的学生研究奖和IBD Plexus奖，共发表SCI论文40余篇，包括Nature、Nature Medicine 、Nature Chemical Biology 、Nature Cell Biology 、Nucleic Acids Research、Molecular Cell、Cell Host & Microbe、Immunity、Journal of Clinical Investigation、Physiological Reviews等。

教育背景：

2012-2018康奈尔医学院休斯顿卫理公会医学 访问博士

2011-2018得克萨斯农工大学 博士

2008-2011中山大学 硕士

2004-2008 深圳大学 荣誉学士

工作经历：

2024.02-至今 助理教授，南方科技大学医学院生物化学系

2024.02-至今 访问学者，麻省理工学院-哈佛大学Broad Institute

2019.10-2024.02 博士后，麻省理工学院-哈佛大学Broad Institute, MIT/HHMI

获奖情况及荣誉：

曾获美国克罗恩病与结肠炎基金会CCFA的学生研究奖

曾获美国克罗恩病与结肠炎基金会CCFA IBD Plexus奖

研究领域：

抗病毒固有免疫

肿瘤免疫逃逸机制与肿瘤免疫治疗

黏膜神经-免疫互作及肠脑轴

发表论文：（# 第一作者；*通讯作者）

1. Tan P*, Hong T, Cai X, Li W, Huang Y, He L*, Zhou Y*. Optogenetic control of protein delivery and partition in the nucleolus. Nucleic Acids Research 2022, 8;50(12):e69.

2. Tan P#, He L#, Huang Y*, Zhou Y*. Optophysiology: Illuminating cell physiology with optogenetics. Physiological Reviews 2022, 102(3):1263-1325.

3. He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Li L, Huang Y, Han G, Wang J, Zhou Y. Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology 2021, 17(8):915-923.

4. Tan P#,*, He L#, Zhou Y*. Engineering supramolecular organizing centers for optogenetic control of innate immune responses. Advanced Biology 2021, 5(5):e2000147.

5. Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang Y, Wang RF. Myeloid loss of Beclin1 promotes PD-L1(hi) precursor B cell lymphoma development. Journal of Clinical Investigation 2019, 129(12):5261-5277. 

6. Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biology 2018, 16(11):e3000051.

7. Zhang J#, Tan P#, Guo L#, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao W, Dashwood R, Han L, Zhou Y, Dong W, Huang Y. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene 2018, 38(11):1905-1919.

8. Zhu Q#, Tan P#, Li Y, Lin M, Cui J, Zhao W, Song Y, Li Q, Akira S, Wang H, Wang RF. DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity. PLoS Pathogens 2018, 14(2): e1006886. 

9. Zhao W#, Zhu Q#, Tan P#, Ajibade A, Long T, Long W, Li Q, Liu P, Ning B, Wang Y, Wang RF. Tgfbr2 inactivation facilitates cellular plasticity and development of Pten-null prostate cancer. Journal of Molecular Cell Biology 2018, 10(4):316-330.

10. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu Xiao, Wang Y, Wang RF. Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling. Molecular Cell 2017, 68 (2): 293-307. 

11. Luo W#, Tan P#, Rodriguez M, He L, Tan K, Siwko S, Liu M. Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition. Journal of Biological Chemistry 2017, 292(37):15525-15537.

12. Tan P#, He L#, Han G, Zhou Y. Optogenetic immunomodulation: shedding light on the antitumor immunity. Trends in Biotechnology 2016, 35(3): 215-226.

13. He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, Zhou Y. Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015, 4: e10024. 

14. Shi H, He Y, Zhou Y, Huang J, Maher K, Wang B, Tang Z, Luo S, Tan P, Wu M, Lin Z, Ren J, Thapa Y, Tang X, Liu A, Liu J, Wang X. Spatial atlas of the mouse central nervous system at molecular resolution. Nature 2023, 622(7983):552-561.

15. Feng C, Tan P, Nie G, Zhu M. Biomimetic and bioinspired nano-platforms for cancer vaccine development. Exploration 2023, 3:20210263.

16. Xie J, Ma G*, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee Y-T, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y*, Zhou Y*, Han W*. Identification of a STIM1 splicing variant that promotes glioblastoma growth. Advanced Science 2022, 9(11):e2103940.

17. He L, Tan P, Huang Y, Zhou Y. Design of smart antibody mimetics with photosensitive switches. Advanced Biology 2021, 5(5):e2000541

18. Xing C, Wang M, Ajibade A, Tan P, Fu C, Chen L, Zhu M, Hao Z, Chu J, Yu X, Yin B, Zhu J, Shen W, Duan T, Wang Y, Wang RF. Microbiota regulate innate immune signaling and protective immunity against cancer. Cell Host & Microbe 2021, 29:1-16.

19. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Fei D, Siwko S, Huang Y, Wang Y, Zhou Y. Engineering of a bona fide light-operated calcium channel. Nature Communications 2021, 12(1):164.

20. Muus C, Luecken M, Eraslan G, Waghray A, Heimberg G, Sikkema L, Kobayashi Y, Dhaval ED, Subramanian A, Smillie C, Jagadeesh K, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber A, Chung H, Montoro D, Adams T, Aliee H, Allon S, Andrusivova Z, Angelidis L, Ashenberg O, Bassier K, Becavin C, Inbal B, Bergenstrahle J, Bergenstrahle L, Bolt L, Braun E, Bui L, Chaffin M, Chichelnitskiy E, Chiou J, Conlon T, Cuoco M, Depre Z, Fisher D, Gillich A, Gould J, Guo M, Gutierrez A, Habermann A, Harvey T, He P, Hou X, Hu L, Jaiswal A, Jiang P, Kapellos T, Kuo C, Larsson L, Leney-Greene M, Lim K, Litvinukova M, Lu J, Maatz H, Maddissoon E, Mamanova L, Manakongtreecheep K, Marquette CH, Mbano I, McAdams AM, Metzger R, Nabhan A, Nyquist S, Ordovas-Montanes J, Penland L, Poirion O, Poli S, Qi C, Reichart D, Rosas I, Schupp J, Sinha R, Sit R, Slowikowski K, Slyper M, Smith N, Sountoulidis A, Strunz M, Sun D, Talavera-Lopez C, Tan P, Tantivit J, Travaglini K, Tucker N, Vernon K, Wadsworth M, Waldman J, Wang X, Yan W, Zhao W, Ziegler C, The NHLBI LungMAP Consortium, The Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine 2021, 27(3):546-559.

21. Zhu M, Deng G, Tan P, Xing C, Guan C, Jiang C, Ning B, Wang H, Chen K, Zhao Y, Wang Y, Levine B, Nie G, Wang RF. Beclin 2 negatively regulates innate immune signaling and tumor development. Journal of Clinical Investigation 2020, 130(10):5349-5369.

22. Liu Z, Li H, He L, Xiang Y, Tian C, Li C, Tan P, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, Zhou Y. Discovery of small molecules inhibitors of the HSP90-Calcineurin-NFAT pathway against glioblastoma. Cell Chemical Biology 2019, 26:1-14.

23. Li A, Cho J, Reid B, Tseng C, He L, Tan P, Yeh C, Wu P, Li Y, Widelitz R, Zhou Y, Zhao M, Chow R, Chuong CM. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications 2018, 9(1):5377.

24. Yu X, Du Y, Cai C, Cai B, Zhu M, Xing C, Tan P, Lin M, Wu J, Wang M, Wang H, Su X, Wang RF. Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity. Nature Communications 2018, 9:4964.

25. Liu K, Zhang C, Li B, Xie W, Zhang J, Nie X, Tan P, Zheng L, Wu S, Qin Y, Cui J, Zhi F. Mutual stabilization between TRIM9 short isoform and MKK6 potentiates p38 signaling to synergistically suppress glioblastoma progression. Cell Reports 2018, 23:838-851.

26. He L, Jing J, Zhu L, Tan P, Ma G, Zhang Q, Nguyen N, Wang J, Zhou Y, Huang Y.Optical control of membrane tethering and interorganellar communication at nanoscales. Chemical Science 2017, 8(8):5275-5283.

27. Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang Y, Su X, Wang RF. Cross-Regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality. Immunity 2016, 45(5):1093-1107.

28. Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Molecular Cell 2016, 64(1):105-119.

29. Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J. USP38 negatively regulates type I interferon signaling by promoting TBK1 degradation through NLRP4 signalosome. Molecular Cell 2016, 64 (2), 267-281.

30. Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nature Cell Biology 2015, 17(10):1339-47.

31. Ma G, Wei M, He L, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications 2015, 6:7826.

32. Cui J, Song Y, Li Y, Zhu Q, Tan P, Qin Y, Wang H, Wang RF.  USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors. Cell Research 2013, 24:400-416.