个人简介：

陈默，医学院药理学系副教授。2013年于新加坡国立大学（National University of Singapore）获得博士学位，2014-2017年于新加坡国立大学从事博士后研究。2017年-2023年于美国威斯康星大学麦迪逊分校（University of Wisconsin Madison）相继任博士后和专职研究员。2023年4月加入南方科技大学医学院药理学系。主要研究方向为细胞器中脂代谢信号通路的分子机制，包括转脂蛋白、磷酸肌醇代谢、脂质与蛋白质复合体、脂质效应蛋白及相关疾病机理。作为第一/共同第一作者在细胞生物学权威期刊Nature Cell Biology 发表论文三篇, Cell Death & Differentiation发表论文两篇，共发表SCI论文13篇。

教育背景：

2009-08 至 2013-12, 新加坡国立大学, 生物学, 博士

2005-09 至 2009-06, 四川大学, 生物技术, 学士

工作经历：

2023-04至今 南方科技大学医学院药理学系，助理教授

2022-07至 2023-03 美国威斯康星大学麦迪逊分校医学院, Senior Scientist

2019-09至 2022-07 美国威斯康星大学麦迪逊分校医学院, Associate Scientist

2017-07至 2019-09 美国威斯康星大学麦迪逊分校医学院, 博士后

2014-01至 2017-06 新加坡国立大学生物系，博士后

获奖情况及荣誉：

2015 新加坡心血管协会优秀青年学者奖励

2009-2013 新加坡国立大学全额奖学金

2009 四川省优秀大学毕业生

2007 国家奖学金

研究领域：

本课题组将利用生物化学、细胞生物学、质谱等多种方法来研究脂代谢信号调控、脂质在细胞器之间的运输、脂质与效应蛋白的复合及生物学功能，了解脂质在细胞器中的非膜结构上的定位以及作用机理，解析疾病中的脂代谢功能异常并以此为靶点开发新型药物。

发表论文： 

1. Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A. A p53-phosphoinositide signalosome regulates nuclear AKT activation. Nat Cell Biol 24, 1099-1113 (2022). https://doi.org:10.1038/s41556-022-00949-1

2. Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A. Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4. Nat Cell Biol 22, 1357-1370 (2020). https://doi.org:10.1038/s41556-020-00596-4

3. Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A. A nuclear phosphoinositide kinase complex regulates p53. Nat Cell Biol 21, 462-475 (2019). https://doi.org:10.1038/s41556-019-0297-2

4. Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R. Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs. Cell Death Differ 25, 1905-1920 (2018). https://doi.org:10.1038/s41418-018-0092-9

5. Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ 21, 797-810 (2014). https://doi.org:10.1038/cdd.2014.3

6. Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A. Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells. Methods Mol Biol 2251, 133-142 (2021). https://doi.org:10.1007/978-1-0716-1142-5_9

7. Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A. The nuclear phosphoinositide response to stress. Cell Cycle 19, 268-289 (2020). https://doi.org:10.1080/15384101.2019.1711316

8. Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al. The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif. Sci Rep 9, 9126 (2019). https://doi.org/10.1038/s41598-019-45671-5

9. Kumar, S. #, Chen, M.# (#共同一作),  Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R. Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. Sci Rep 6, 31130 (2016). https://doi.org:10.1038/srep31130

10. Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine 33, 22-32 (2018). https://doi.org:10.1016/j.ebiom.2018.06.004

11. Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R. Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability. Angiogenesis 21, 653-665 (2018). https://doi.org:10.1007/s10456-018-9616-7

12. Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R. Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation. Cardiovasc Res 107, 131-142 (2015). https://doi.org:10.1093/cvr/cvv142

13. Zhang, Y., Chen, M., Venugopal, S., Zhou, Y., Xiang, W., Li, Y. H., Lin, Q., Kini, R. M., Chong, Y. S. & Ge, R. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis 2, e153 (2011). https://doi.org:10.1038/cddis.2011.37