个人简介：

廖茂富，生命科学学院讲席教授，博士生导师。1999年毕业于清华大学生物科学与技术系，2006年获美国爱因斯坦医学院博士学位，之后在加州大学旧金山分校进行博士后工作。2014年至2022年，先后任哈佛大学医学院助理教授、副教授。主要使用冷冻电镜和生物化学方法研究生物大分子的结构与机制。于2022年7月全职回国加入南方科技大学生命科学学院。

研究领域：

廖茂富课题组的研究领域包括：

1. 发展生物电镜方法学以开拓新科研领域；

2. 揭示生物大分子运作的精细机制；

3. 使用生物的结构和机制信息来革新医疗手段。

代表文章： 

1: Liu D*, Thélot FA*, Piccirilli JA, Liao M#, Yin P#. Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly. Nat Methods. 2022 May;19(5):576-585. doi: 10.1038/s41592-022-01455-w. Epub 2022 May 2. PMID: 35501384.

2: Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M. Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science. 2021 Oct 29;374(6567):580-585. doi: 10.1126/science.abi9009. Epub 2021 Sep 23. PMID: 34554829; PMCID: PMC9109178.

3: Sharma S*, Zhou R*, Wan L, Feng S, Song K, Xu C, Li Y#, Liao M#. Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins. Nat Commun. 2021 Aug 3;12(1):4687. doi: 10.1038/s41467-021-24965-1. PMID: 34344901; PMCID: PMC8333309.

4: Orlando BJ, Liao M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun. 2020 May 8;11(1):2264. doi: 10.1038/s41467-020-16155-2. PMID: 32385283; PMCID: PMC7210939.

5: Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M#, Walther TC#, Farese RV Jr.# Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May 13. PMID: 32433611; PMCID: PMC7398557.

6: Li Y*, Orlando BJ*, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature. 2019 Mar;567(7749):486-490. doi: 10.1038/s41586-019-1025-6. Epub 2019 Mar 20. PMID: 30894744; PMCID: PMC6532066.

7: Srivastava AP*, Luo M*, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M#, Mueller DM#. High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane. Science. 2018 May 11;360(6389):eaas9699. doi: 10.1126/science.aas9699. Epub 2018 Apr 12. PMID: 29650704; PMCID: PMC5948177.

8: Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature. 2017 Sep 14;549(7671):233-237. doi: 10.1038/nature23649. Epub 2017 Sep 6. PMID: 28869968; PMCID: PMC5759761.

9: Schoebel S*, Mi W*, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA#, Liao M#. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 Aug 17;548(7667):352-355. doi: 10.1038/nature23314. Epub 2017 Jul 6. PMID: 28682307; PMCID: PMC5736104.

10: Liao M*, Cao E*, Julius D#, Cheng Y#. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 5;504(7478):107-12. doi: 10.1038/nature12822. PMID: 24305160; PMCID: PMC4078027.

课题组网站：https://liao.bio.sustech.edu.cn/