基本概况

李职秀博士，公共卫生及应急管理学院副教授（研究员），博士生导师。主要研究方向为免疫疾病等慢病和复杂疾病的致病机理，早期诊断和精准干预，以及传染性疾病疫苗的开发。曾主持和参与多项澳大利亚国家级、州政府级和企业科研项目。在Nature Genetics, Annals of the Rheumatic Diseases, PLos Genetics, Nature Reviews Rheumatology, Annal Review of Biophysics等权威SCI杂志发表论文40余篇 。现为Frontiers in Immunology 杂志客座编辑。曾担任Nature Genetics, Nature Communications, Arthritis & Rheumatology, JAMA Network Open等多个SCI期刊审稿专家。曾任澳大利亚、英国和法国等国际基金会的通讯评审。多次在American College of Rheumatology年会，亚太风湿病学会联盟大会（APLAR）等国际会议上做大会报告和口头学术报告，获得2019 APLAR最佳摘要奖。为国际强直性脊柱炎遗传学联盟（International Genetics of Ankylosing Spondylitis，IGAS）成员。

研究方向 

1． 免疫疾病等慢病和复杂疾病的遗传和非遗传病因 

2． 强直性脊柱炎等疾病的早期诊断，精准干预和管理，以及相关方法的开发 

3． 针对重大传染性疾病和病毒的精准疫苗设计

工作经历

2023.12-至今        南方科技大学，公共卫生与应急管理学院，副教授

2023.06-2023.12  南方科技大学，公共卫生与应急管理学院，助理教授

2018-2022           昆士兰科技大学 Vice-Chancellor Research Fellow

2016-2018           昆士兰科技大学 博士后

2014-2016           昆士兰大学 博士后

教育经历

2009-2015 印第安纳大学 信息学院 博士

2005-2009 中国科学技术大学 生命科学院 学士

代表性论文（#共同一作，*通讯作者）

1.  Li, Z., McRae, A. F., Wang, G., et al. Genotype by sex interactions in ankylosing spondylitis. Nat. Genet. 55, 14–16 (2023).

2.  Li, Z., Khan, M. K., Linden, S. M. van der, et al. HLA-B27, axial spondyloarthritis and survival. Ann. Rheum. Dis. (2023) doi:10.1136/ard-2023-224434.

3.  Li, Z., Linden, S. M. van der, Khan, M. A., et al. Heterogeneity of axial spondyloarthritis: genetics, sex and structural damage matter. RMD Open 8, e002302 (2022).

4.  Williams, C. J#., Li, Z.#, Harvey, N#., et al. Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study. J. Biomed. Sci. 28, 37 (2021).

5.  Li, Z., Wu, X., Leo, P. J., et al. Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis. Ann. Rheum. Dis. 80, 1168–1174 (2021).

6.  Wang, G., Kim, T.-H., Li, Z.#, et al. MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions. Arthritis Res. Ther. 22, 74 (2020).

7.  Li, Z., Akar, S., Yarkan, H., et al. Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis. PLOS Genet. 15, e1008038 (2019).

8.  Li, Z. & Brown, M. A. Progress of genome-wide association studies of ankylosing spondylitis. Clin. Transl. Immunol. 6, e163 (2017).

9.  Li, Z., Haynes, K., Pennisi, D. J., et al. Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis. Genes Immun. 18, 135–143 (2017).

10. Li, Z., Yang, Y., Faraggi, E., Zhan, J. & Zhou, Y. Direct prediction of profiles of sequences compatible with a protein structure by neural networks with fragment-based local and energy-based nonlocal profiles. Proteins Struct. Funct. Bioinforma. 82, 2565–2573 (2014).

11. Li, Z., Yang, Y., Zhan, J., Dai, L. & Zhou, Y. Energy Functions in De Novo Protein Design: Current Challenges and Future Prospects. Annu. Rev. Biophys. 42, 315–335 (2013).