李逸明
研究教授
生物医药创新中心
E-mail: liym3@sustech.edu.cn

 

研究方向

用于生产重组蛋白的分子生物学、细胞生物学和生物化学技术的研发；蛋白质纯化、药用蛋白质质量及稳定性分析；用于合成化学药物及中间体的生物酶催化剂的研究及开发；酶固定化技术。

 

教育经历

1994.08  – 1997.11   瑞典乌普萨拉大学生物化学系，博士（获生物化学博士学位）

1985.03  – 1988.08   中山大学生物系，博士（获动物学博士学位）

1982.03  – 1985.01   中山大学生物系，硕士

1978.03  – 1982.01   中山大学生物系，学士

 

工作经历

2018.10 – 至今          南方科技大学，研究教授

2016.10 – 2018.09    美国Biosolutions-Plus，首席科学官

2009.09 – 2016.08    美国MedImmune（阿斯利康），科学家II

2002.05 – 2009.09    美国人类基因组公司，科学家、高级科学家

1998.08 – 2002.04    哈佛大学医学院，博士后

1997.12 – 1998.07    瑞典乌普萨拉大学，博士后

1990.01 – 1994.07    乌瑞典普萨拉大学植物、卡洛林斯卡皇家医学研究院，博士后

1988.09 – 1989.12    深圳市科委 科技交流中心，工程师

 

代表性论文

1. Li YM, Polozova A, Gruia F, and Feng J. (2014) Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores. Analytical Chemistry, 86: 6850-6857.

2. Li YM, Stafford W, Hesselberg M, Hayes D, Wu Z. Byrne M. (2011) Characterization of the self-association of human interferon-α2b, albinterferon-α2b, and pegasys. Journal of Pharmaceutical Sciences. 101-1: 68–80

3. Irwin N, Li YM, O’toole JE and Benowitz, L. (2006) Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Natl. Acad. Sci. USA 103(48): 18320-18325.

4. Li YM, Irwin N, Yin YQ, Lanser M and Benowitz L. (2003) Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP. J. Neurosci. 23 (21): 7830-7838.

5. Liu CM, Li YM, Semenov M, Han C, Baeg GH, Tan Y, Zhang ZH, Lin XH and He X.  (2002) Control of -catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.

6. Gottschalk I, Li YM and Lundahl P. (2000) Chromatography on cells: Analysis of solute interactions with the glucose transporter Glut 1 in human red cells adsorbed on lectin-gel beads. J Chromat B  Biomed Sci Appl. 739 (1) 55-62.

7. Li YM, Liao JL, Zhang R, Henriksson H and Hjerten S. (1999) Continuous beds for microchromatography: chromatogocusing and anion exchange chromatography. Anal Biochem. 267 (1): 121-124.

8. Li YM, Franklin G, Cui HM, Svensson K, He XB, Adam G, Ohlsson R and Pfeifer S. (1998) The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. J Biol Chem 273: 28247-28252.

9. Hjerten S, Ericson C, Li YM and Zhang R. (1998) Capillary electrophoresis and capillary chromatography. Theoretical analogies and practical differences. Biomed Chromatogr.12: 120-121.

10. Liao JL, Li YM and Hjerten S. (1996) Continuous beds for microchromatography: reversed phase chromatography. Anal Biochem. 234: 27-30.

11. Li YM, Brostedt P, Hjerten S, Nyberg F and Silberring J. (1995) Capillary LC-FAB MS using a high-resolving cation-exchanger, based on a continuous chromatographic matrix. Application to studies on neuropeptide peptidases. J Chromatogr B. 664: 426-430.

12. Li YM, Liao JL, Nakazato K, Mohammad J, Terenius L and Hjerten S. (1994) Continuous bed for microchromatography: cation-exchange chromatography. Anal Biochem. 223: 153-158.

13. Silberring J, Li YM, Nyberg F. and Hjerten S. (1993) Strategies in studies on neuropeptide processing by mass spectrometry. Biochem Soc Trans. 22: 136-140.

14. Mohammad J, Li YM, El-Ahman M, Nakazato K, Pettersson G and Hjerten S. 1993. Chiral-recognition chromatography of b-blockers on continuous polymer beds with immobilized cellulase as enantioselective protein. Chirality 5: 464-470.

15. Hjerten S, Li YM, Liao JL, Mohammad J, Nakazato K and Pettersson G. (1992) Continuous beds: high-resolving, cost-effective chromatographic matrices. Nature 356: 810-811.

16. Jiang JB and Li YM (1988) Sarcocystosis induced by Sarcocystis suihominis in China. In “Zoonoses in China” (Yu ES and Xu BK eds.) pp.888-891.

17. Li YM and Lian ZQ (1986) Studies on man-pig cyclic infection of Sarcocystis suihominis found in Yunnan Province, China. Acta Zoologica Sinica 32(4): 329-334.

 

专利

1. 中国专利(已提交)：通过点突变在毕赤酵母中表达有活性的嗜热脂肪芽胞杆菌脂肪酶。

申请人：王瑞工、刘伊佳、李逸明

2. 美国专利：Method of Purifying albumin-fusion proteins

申请人：Pabst, Timothy; Fonsecaf, Mariko; Thompson, Christopher

Hunter, Alan；Wang, Xiangyang；Tie, Liu；LI, Yiming

申请号：US2016/022003

发表日期：2016年9月15日