个人简介：

       南方科技大学医学院药理学系副教授、博士生导师。

       2006年在德国马克斯普朗克分子遗传所获得功能基因组学博士学位，07年于同所建立独立实验室。2009年任德国马科斯德尔布吕克国家分子医学中心/柏林系统生物医学研究所高级研究员。2016年8月加入南方科技大学。

      长期从事功能基因组、药理学、化学生物学领域的研究，在新药研发方面也富有经验。聚焦功能基因组学领域的研究，曾建立基于细胞芯片技术的包括蛋白质亚细胞定位，诱导细胞凋亡，蛋白质－蛋白质交互作用等多项高通量基因功能研究平台。近年来，致力于发展适用于药理学的系统生物学手段，特别是结合高通量测序、单细胞测序技术、空间转录组学技术、CRISPR基因编辑技术、蛋白组学、代谢组学等的前沿技术。已在Genome biology, Oncogene, EMBO Molecular medicine，Developmental cell等期刊, 发表40余篇研究论文，总引用近2000次，近5年引用数超1000次。H-指数18，i10-指数22。已申请抗肿瘤、抗新冠的天然化合物，单细胞技术等发明专利8项。已承担国家和省市项目4项，总科研经费超560万元。

      深圳市孔雀团队核心成员，深圳市基因调控与系统生物学重点实验室核心PI。现任中国药理学会抗炎免疫专委会委员、广东省药理学会理事、抗炎免疫专委会主任委员。广东欧美同学会常务理事。

教育背景：

2002.09-2006.06  德国马普分子遗传学研究所，功能基因组学，博士

1998.09-2001.06  华西医科大学（后四川大学），药学院，生药学，硕士

1990.09-1994.06  成都中医药大学，中药学，学士

工作经历：

2022.03-至今   南方科技大学医学院药理学系，副教授、研究员

2016.08-2022.03 南方科技大学生物系，独立PI, 研究副教授，博士生导师
2009-2016 德国马科斯•德尔布吕克国家分子医学中心，高级研究员
2007-2009 德国马普分子遗传学研究所，青年科学家小组（化学及药物基因组学）组长
2006-2007 德国马普分子遗传学研究所，博士后
2002.1-2002.10 香港浸会大学，访问学者
1994-2002 华西医科大学（2001年并入四川大学）药学院，助教，讲师（1999起)

获奖情况及荣誉：

2021年    深圳市产业发展与创新人才奖

2020年    南方科技大学校优秀专利奖    

研究领域：

1.基于功能基因组，特别是结合高通量测序、单细胞时空组学、CRISPR基因编辑技术的药物功能和分子机制研究。

2. 基于精准医疗的肿瘤基因组学和化学基因组学，致力于癌症的耐药逆转、早期检测和分类靶向治疗。

3.结合组学、化学生物学的细胞生物学研究。尤以化合物诱导的细胞焦亡、线粒体功能异常、DNA损伤和修复，及其在表观遗传学的改变为主要研究方向。

4. 基于新作用机理的化合物（含天然产物）临床前新药研发。

学术任职：

1、 担任中国药理学会抗炎免疫专委会委员；

2、 担任广东省药理学会理事

3、担任广东省药理学会抗炎免疫专委会副主任委员；

4、担任中药全球化联盟会员；

5、担任国际化学生物学学会会员；

6、担任德中分子医学和分子药学学会会员；

7、担任广东欧美同学会常务理事

发表论文：

1. Mingyue Wang, Qinan Hu, Tianhang Lv, Yuhang Wang, Qing Lan, Zhencheng Tu, Rong Xiang, Yanrong Wei, Kai Han, Yanru An, Mengnan Cheng, Jiangshan Xu, Miguel A.Esteban, Haorong Lu, Wangsheng Li, Shaofang Zhang, Ao Chen, Wei Chen, Yuxiang Li, Xiaoshan Wang, Xun Xu*, Yuhui Hu*, Longqi Liu*. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Developmental cell，2022，Volume 57, Issue 10, Pages 1271-1283.e4

 https://doi.org/10.1016/j.devcel.2022.04.006

2. Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Hao Wang, Yan Zhao, Ziying Gao, Yanxiang Jiang, Li Zhao, Hao Gao*, Xinsheng Yao, Yuhui Hu*. Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells. Pharmacological Research, 2022, Volume 182, 106285. https://doi.org/10.1016/j.phrs.2022.106285

3. Shuye Tian, Bin Zhang, Yuhao He, Zhiyuan Sun, Jun Li, Yisheng Li, Hongyang Yi, Yan Zhao, Xudong Zou, Yunfei Li, Huanhuan Cui, Liang Fang, Xin Gao, Yuhui Hu, Wei Chen*. CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference. Nucleic Acids Research, 2022, gkac108.

4. Weizheng Liang, Guipeng Li, Huanhuan Cui, Yukai Wang, Wencheng Wei, Siyue Sun, Diwen Gan, Rui Chen, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Wei Chen*. Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents, BMC Genomics, 2021 (in presss) DOI: 10.21203/rs.3.rs-511600/v1

5. Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen*. Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law. Life Science Alliance (2021) 5(4):e202101333.

6. Yan Zhao, Jing Sun, Yunfei Li, Zhengxuan Li, Yu Xie, Ruoqing Feng, Jincun Zhao*, Yuhui Hu*. The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir. iScience (2021)24 (8): 102857. DOI: 10.1016/j.isci.2021.102857

7. Liang Fang, Guipeng Li, Zhiyuan Sun, Qionghua Zhu, Huanhuan Cui, Yunfei Li, Jingwen Zhang, Weizheng Liang, Wencheng Wei, Yuhui Hu & Wei Chen*. CASB: a concanavalin A‐based sample barcoding strategy for single cell Sequencing.  Molecular systems biology (2021) 17 (4): e10060.

8. Zhongxiao Li, Yisheng Li, Bin Zhang, Yu Li, Yongkang Long, Juexiao Zhou, Xudong Zou, Min Zhang, Yuhui Hu*, Wei Chen*, Xin Gao*. DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning. Genomics Proteomics and Bioinformatics, (2021), In press. https://doi.org/10.1016/j.gpb.2020.05.004

9. Liang Fang*, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu and Wei Chen*. CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators. Mol Syst Biol (2020) 16:e10025.

10. Hongyang Yi, Guipeng Li, Yongkang Long, Weizheng Liang, Huanhuan Cui, Bin Zhang, Ying Tan, Yunfei Li, Luochen Shen, Daqi Deng, Yisen Tang, Chenyu Mao, Shuye Tian, Yunting Cai, Qionghua Zhu, Yuhui Hu*, Wei Chen* & Liang Fang*. Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene (2020)39:5152–5164.  DOI: 10.1038/s41388-020-1351-z

11. Yisheng Li , Bernhard Schaefke* , Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu & Wei Chen*. Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation. Mol Syst Biol (2020) 16: e9367.

12. Xi Wang, Xintian You, Julian Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin Schuman, and Wei Chen. Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nat Commun (2019) 10:5009.

13. Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Fro hler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl*, Utz Fischer*, and Wei Chen*. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLOS Genetics (2019) 15(10): e1008460.

14. Haiping Zhang, Linbu Liao, Yunting Cai, Yuhui Hu, Hao Wang*. IVS2vec: A tool of Inverse Virtual Screening based on word2vec and deep learning techniques, Methods (2019) 166:57–65.

15. Zhihao Xia, Yu Li , Bin Zhang, Zhongxiao Li, Yuhui Hu, Wei Chen*, and Xin Gao*. DeeReCT-PolyA: a robust and generic deep learning method for PAS identification. Bioinformatics (2019)35(14):2371–2379.

16. Wei Sun, Qingsong Gao, Bernhard Schaefke, Yuhui Hu, Wei Chen*. Pervasive allele-specific regulation on RNA decay in hybrid mice. Life science alliance (2018) 1 (2):e201800052.

17. Wang, Y., Gogol-Döring, A., Hu, H., Fröhler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y.* and Chen, W.*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. (2013) Sep;5(9):1431-42.

18. Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*. Widespread splicing changes in human brain development and aging. Mol Syst Biol. (2013); 9:633.

19. Li N, You X, Chen T, Mackowiak SD, Friedländer MR, Weigt M, Du H, Gogol-Döring A, Chang Z, Dieterich C, Hu Y, Chen W*. Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. (2013) Apr 1;41(6):3619-34.

20. Thu-Hang Pham, Christopher Benner, Monika Lichtinger, Lucia Schwarzfischer, Yuhui Hu, Reinhard Andreesen, Wei Chen and Michael Rehli. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states.  Blood. (2012) Jun 14;119(24):e161-71.

21. Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. (2012) Apr;22(4):611-22.

22. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. PLoS Biol. (2011) Dec;9(12):e1001214.

23. Zheng Yan, Hai Yang Hu, Xi Jiang, Vera Maierhofer, Elena Neb, Liu He, Yuhui Hu, Hao Hu, Na Li, Wei Chen, and Philipp Khaitovich. Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. (2011) Aug;39(15):6596-607.

24. Yuhui Hu and Michal Janitz. High-throughput subcellular protein localization using transfected-cell arrays. Methods Mol Biol. (2011);706:53-72.

25. Mehmet Somel, Song Guo, Ning Fu, Zheng Yan, Hai Yang Hu, Ying Xu, Yuan Yuan, Zhibin Ning, Yuhui Hu, Corinna Menzel, Hao Hu, Michael Lachmann, Rong Zeng, Wei Chen, and Philipp Khaitovich. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Research (2010); 20:1207-1218.

26. Weimin Qiu, Yuhui Hu, Tom E. Andersen, Abbas Jafari, Na Li, Wei Chen, and Moustapha Kassem. Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical WNT signaling and C/EBP. J Biol Chem. (2010); 7;285(19):14438-49.

27. Yuhui Hu, Hans Lehrach and Michal Janitz. Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Molecular Biology Reports (2010); 37(7): 3381–3387.

28. Chen W, Ullmann R, Langnick C, Menzel C, Wotschofsky Z, Hu H, Döring A, Hu Y, Kang H, Tzschach A, Hoeltzenbein M, Neitzel H, Markus S,Wiedersberg E, Kistner G, van Ravenswaaij-Arts CM, Kleefstra T, Kalscheuer VM, Ropers HH. Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing. Eur J Hum Genet. (2010) May;18(5):539-43.

29. Yuhui Hu, Hans Lehrach and Michal Janitz. Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods. Journal of Molecular Histology. (2009) Oct;40(5-6):343-52.

30. Fiebitz A, Nyarsik L, Haendler B, Hu YH, Wagner F, Thamm S, Lehrach H, Janitz M, Vanhecke D. High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays. BMC Genomics (2008), 9:68.

31. Y.H. Hu, H. J. Warnatz, D. Vanhecke, F. Wagner, A. Fiebitz, S. Thamm, P. Kahlem, H. Lehrach, M. L. Yaspo, and M. Janitz. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.  BMC Genomics (2006), 7:155.

32. Y.H. Hu, D. Vanhecke, M. Janitz. High-throughput subcellular protein localization using cell arrays. Biochemical Society Transaction. (2005) Dec;33(Pt 6):1407-8.

33. Liu L, Han L, Wong DYL, Yue PYK, Ha WY, Hu YH, Wang PX, Wong RNS. Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells. British Journal of Nutrition. (2005) 93, 21–29.

34. Hu Yuhui, ZHANG Hao, Zhang Zhi-Feng. Determine total flavonoids and scutellarin of Erigeron genus. Chin. J. Pharm. Anal. (2005) 25(1).

35. Hu Yuhui, ZHANG Hao. Chemical comparative study on the active compounds in 5 species of Erigeron. The journal of Chinese Traditional Patent Medicine (2004) Jan.

36. 张志锋，张浩，胡宇慧，刘显福。不同产地多舌飞蓬化学成分的含量测定。《中国民族民间医药杂志》，2003年 2期

37. 胡宇慧，张浩等。欧洲两地和中国西南山区飞蓬挥发油成份的比较。《华西药学杂志》， 2001年16卷3期