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覃刚健
讲席教授
0755-8801 5695
qingj@sustech.edu.cn

个人简介：

覃刚健，南方科技大学医学院讲席教授，博士生导师。毕业于武汉同济医科大学，获医学学士（1981-1986）和硕士（1986-1989）学位；毕业后留校附属协和医院儿科，历任住院医生、主治医师和医学讲师（1989-1995）。后赴意大利国际遗传工程和生物技术中心（1995–1998）和美国伊利诺伊大学芝加哥校区（1998–2001）接受博士后研究训练。此后，曾在波士顿塔夫茨大学圣伊丽莎白医学中心任医学讲师、助理教授（2001–2006），芝加哥西北大学芬伯格医学院心血管研究所、心内科任助理教授、副教授（2007–2016），阿拉巴马大学（伯明翰）任教授，分子心脏病学主任，生物医学工程系副主任（2016–2022）。 覃教授多年来从事心血管系统发育、干细胞生物学、和缺血性心脏病的病理生理学研究，并致力于心肌和血管损伤的发生机理，以及组织保护、修复、和再生的治疗策略探索。在该领域完成了一系列原创性工作并取得重要研究成果，包括揭示E2F家族转录因子在血管形成和血压稳态中的作用；分离鉴定独特的心脏干细胞群；揭示CXCR4介导的骨髓干细胞微环境的信号机制，并建立内源性干细胞在缺血组织修复中的重要性，以及氧化代谢在其分化中的关键作用；实现体内示踪和分离组织特异外泌体，并揭示缺血心肌外泌体的全身系统性作用；建立Sam68在能量稳态、糖脂代谢、肥胖和2型糖尿病的重要调节作用。 覃教授在主流学术期刊上发表原创性论文130余篇，主持多项美国国立卫生研究院（NIH）、心脏病协会（AHA）、和糖尿病协会 (ADA) 项目。此外，覃教授还先后受聘为Circulation Research等10余种SCI期刊的编委，以及包括NIH、AHA、退伍军人事务（VA）在内的多个美国、和国际基金组织的评审委员或主持，并在美国心脏协会基础学会（BCVS）、心血管放射学和干预委员会（CVRI）等专业协会担任学术领导工作。在过去的18年里，覃教授成功培养了50多名不同职业阶段的科研人员。

 

教育背景：

  • 1981.09–1981.07 同济医科大学（现华中科技大学同济医学院）儿科系；获医学学士学位

  • 1986.09–1989.12 同济医科大学儿科学新生儿专业；获医学硕士学位

 

工作经历：

  • 1989.12–1992.08 住院医生；同济医科大学附属协和医院儿科

  • 1992.09–1995.10 主治医师，医学讲师；同济医科大学附属协和医院儿科

  • 1995.10–1998.08 博士后；意大利国际遗传工程和生物技术中心，分子医学组

  • 1998.10–2001.04 博士后；美国伊利诺伊大学（芝加哥），血液/肿瘤科

  • 2001.04–2004.08 医学讲师；美国塔夫茨大学附属圣伊丽莎白医学中心（波士顿），心血管科

  • 2004.09–2006.12 助理教授；美国塔夫茨大学附属圣伊丽莎白医学中心（波士顿），心血管科

  • 2007.01–2012.08 助理教授；美国西北大学芬伯格医学院（芝加哥），心内科，心血管研究所

  • 2012.09–2016.06 副教授；美国西北大学芬伯格医学院（芝加哥），心内科，心血管研究所

  • 2016.07–2022.09 教授，分子心脏病主任，生物医学工程系副主任（自2017年11月）；美国阿拉巴马州立大学医学院，工程学院（伯明翰）

  • 2022.09–至今 讲席教授；南方科技大学医学院（深圳）

     

获奖情况及荣誉：

  • 2004 美国心脏协会Melvin Marcus 心血管科学青年研究员奖 (Melvin Marcus Young Investigator Award in Cardiovascular Sciences, Finalist)

  • 2007 西北大学范伯格医学院研究人员学术奖 (Investigators Developing Excellence in Academics Award)

  • 2007 西北大学Searle教学奖 (Searle Fellow for Teaching Excellence)

  • 2010 美国心脏协会荣誉会员（FAHA）

  • 2018–2020 美国心血管卓越研究院 (ACRE)，主席

  • 2022 深圳市鹏城特聘 （A类）

 

研究领域：

  • 缺血损伤，器官保护与修复

  • 心肌再生

  • 干细胞与干细胞产品的治疗转化

  • 糖脂和能量代谢

 

学术任职：

  • 2016–2020 美国心脏协会基础学会 (BCVS)：会员与国际交流管理委员会

  • 2017–2021美国心脏协会心血管放射学和介入委员会 (CVRI): CVRI和PVD血管成像和介入委员会

  • 2020–2023 美国心脏协会基础学会 (BCVS)：学术管理委员会

 

发表论文：

Representative publications (from a total of 130)

  1. Zentilin L.*, Qin G.*, Tafuro S., Dinauer M.C., Baum C., and Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Ther 2000 Jan; 7(2):153-66. doi: 10.1038/sj.gt.3301057. PMID: 10673720

  2. Qin G., Takenaka T., Telsch K., Kelley L., Howard T., Levade T., Deans R., Howard B.H., Malech H.L., Brady R.O., and Medin J.A. Preselective gene therapy for Fabry disease. Proc Natl Acad Sci U S A 2001 Mar 13; 98(6):3428-33. doi: 10.1073/pnas.061020598. PMID: 11248095 PMCID: PMC30670

  3. Yoon Y.S., Wecker A., Heyd L., Park J.S., Tkebuchava T., Kusano K., Hanley A., Scadova H., Qin G., Cha D.H., Johnson K.L., Aikawa R., Asahara T., and Losordo D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005 Feb 1; 115(2):326-38. doi: 10.1172/JCI22326 PMID: 15690083 PMCID: PMC546424

  4. Kishore R., Qin G., Luedemann C., Bord E., Hanley A., Silver M., Gavin M., Yoon Y.S., Goukassian D., and Losordo D.W., The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 2005 Jun 16; 115(7):1785-96. doi: 10.1172/JCI22849 PMID: 15965500 PMCID: PMC1150283

  5. Ii M., Nishimura H., Kusano K.F., Qin G., Yoon Y.S., Wecker A., Asahara T., and Losordo D.W., Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation 2005 Jul 5; 112(1):93-102. doi: 10.1161/CIRCULATIONAHA.104.511964 PMID: 15983249

  6. Qin G., Ii M., Silver M., Wecker A., Bord E., Ma H., Gavin M., Goukassian D.A., Yoon Y.S., Papayannopoulou T., Asahara T., Kearney M., Thorne T., Curry C., Eaton L., Heyd L., Dinesh D., Kishore R., Zhu Y., and Losordo D.W., Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 2006 Jan 23; 203(1):153-63. DOI: 10.1084/jem.20050459. PMID: 16401693 PMCID: PMC2118065

  7. Iwakura A., Shastry S., Luedemann C., Hamada H., Kawamoto A., Kishore R., Zhu Y., Qin G., Silver M., Thorne T., Eaton L., Masuda H., Asahara T., and Losordo D.W., Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006 Mar 28; 113(12):1605-14. doi: 10.1161/CIRCULATIONAHA.105.553925 PMID: 16534014

  8. Qin G., Kishore R., Dolan C.M., Silver M., Wecker A., Luedemann C.N., Thorne T., Hanley A., Curry C., Heyd L., Dinesh D., Kearney M., Martelli F., Murayama T., Goukassian D.A., Zhu Y., and Losordo D.W., Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A 2006 Jul 18; 103(29):11015-20. doi: 10.1073/pnas.0509533103. PMID: 16835303 PMCID: PMC1544166

  9. Hamada H., Kim M.K., Iwakura A., Ii M., Thorne T., Qin G., Asai J., Tsutsumi Y., Sekiguchi H., Silver M., Wecker A., Bord E., Zhu Y., Kishore R., and Losordo D.W., Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation 2006 Nov 21; 114(21):2261-70. doi: 10.1161/CIRCULATIONAHA.106.631465. PMID: 17088460

  10. Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., and Losordo D.W., Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation 2007 Feb 13; 115(6):752-62. doi: 10.1161/CIRCULATIONAHA.106.647255. PMID: 17261656

  11. Rajasingh J., Bord E., Hamada H., Lambers E., Qin G., Losordo D.W., and Kishore R., STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ Res 2007 Oct 26; 101(9):910-8. doi: 10.1161/CIRCRESAHA.107.156786. PMID: 17823373

  12. Cho H.J., Lee N., Lee J.Y., Choi Y.J., Ii M., Wecker A., Jeong J.O., Curry C., Qin G., and Yoon Y.S., Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007 Dec 24; 204(13):3257-69. doi: 10.1084/jem.20070166. PMID: 18070934 PMCID: PMC2150988

  13. Rajasingh J., Lambers E., Hamada H., Bord E., Thorne T., Goukassian I., Krishnamurthy P., Rosen K.M., Ahluwalia D., Zhu Y., Qin G., Losordo D.W., and Kishore R., Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res 2008 Jun 6; 102(11):e107-17. doi: 10.1161/CIRCRESAHA.108.176115. PMID: 18483406 PMCID: PMC2435186

  14. Krishnamurthy P., Rajasingh J., Lambers E., Qin G., Losordo D.W., and Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 2009 Jan 30; 104(2):e9-18. doi: 10.1161/CIRCRESAHA.108.188243. PMID: 19096025 PMCID: PMC2774810

  15. Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 2009 May 22; 104(10):1209-16 (Editorial commended). doi: 10.1161/CIRCRESAHA.109.197723. PMCID: PMC2756190

  16. Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G., Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation 2009 Sep 29; 120(13):1213-21. doi: 10.1161/CIRCULATIONAHA.109.859207. PMCID: PMC2785027. (Editors pick)

  17. Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang  Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G., CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 2010 Oct 29; 107(9):1083-93 doi: 10.1161/CIRCRESAHA.110.220970. PMID: 20847314 PMCID: PMC2966940 (Cover featured; Editors pick)

  18. Sahoo S, Klyachko E, Thorne T, Misener S, Shinnick K, Millay M, Ito A, Liu T, Kamide C, Agarwal H, Perlman H, Qin G.,Kishore R, Losordo DW. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Circ Res 2011 Sep 16; 109(7):724-8. doi: 10.1161/CIRCRESAHA.111.253286. PMID: 21835908. PMCID: PMC3201702

  19. Krishnamurthy P., Thal M., Verma S.K., Hoxha E., Lambers E., Ramirez V., Qin G., Losordo D.W., and Raj Kishore. IL-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res 2011 Nov 11; 109(11):1280-9. doi: 10.1161/CIRCRESAHA.111.248369. PMID: 21959218 PMCID: PMC3235675

  20. Thal MA, Krishnamurthy P, Mackie AR, Hoxha E, Lambers E, Verma S, Ramirez V, Qin G, Losordo DW, Kishore R.  Enhanced Angiogenic and Cardiomyocyte Differentiation Capacity of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Augments their Efficacy for Ischemic Myocardial Repair. Circ Res 2012 Jul 6; 111(2):180-90. doi: 10.1161/CIRCRESAHA.112.270462. PMID: 22589373 PMCID: PMC3406600

  21. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A, Kishore R. IL-10 Treatment Attenuates Pressure Overload-Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nulcear Factor-kB. Circulation 2012 Jul 24; 126(4):418-29. doi: 10.1161/CIRCULATIONAHA.112.112185. PMID: 22705886 PMCID: PMC3422741

  22. Cheng M. and Qin G., Progenitor cell mobilization and recruitment: SDF-1, CXCR4, a4-integrin, and c-kit, Prog Mol Biol Transl Sci. 2012; 111:243-64. PMID: 22917234. DOI: 10.1016/B978-0-12-398459-3.00011-3 PMCID: PMC3556394 (Invited Review)

  23. Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault M-A, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, MD, Losordo DW.  CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism. Circulation 2013 Jan 1; 127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. PMID: 23204107 PMCID: PMC3560409

  24. Zhou J, Cheng M, Liao Y, Hu Y, Wu M, Wang Q, Qin B, Hong W, Zhu Y, Gao YM, Goukassian D, Zhao TC, Tang YL, Raj Kishore, Qin G. Rosuvastatin enhances angiogenesis via eNOS–dependent mobilization of endothelial progenitor cells PLoS ONE 2013 May 21; 8(5):e63126:1-7. doi: 10.1371/journal.pone.0063126. PMID: 23704894 PMCID: PMC3660394

  25. Zhou J, Xu S, Cheng M, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in cardiac neovascularization PLoS ONE 2013 Jun 14; 8(6): e65755. doi:10.1371/journal.pone.0065755. PMID: 23799044 PMCID: PMC3683051

  26. Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhou TC, Tang YL, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013 Jul; 60:68-71. doi: 10.1016/j.yjmcc.2013.04.009. PMID: 23603666 PMCID: PMC3684263

  27. Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3-regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 2013 Oct 25; 113(10):1148-58. doi: 10.1161/CIRCRESAHA.113.301546. PMID: 24044950 PMCID: PMC4339272

  28. Tongers J, Webber MJ, Vaughan EE, Sleep E, Renault M-A, Roncalli JG, Klyachko E, Thorne T, Yu Y, Marquardt K-T, Kamide CE, Ito A, Misener S, Millay M, Liu T, Jujo K, Qin G, Losordo DW, Stupp SI, Kishore R. Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix, J Mol Cell Cardiol 2014 Sep; 74:231-9. doi: 10.1016/j.yjmcc.2014.05.017. PMID: 25009075 PMCID: PMC4135436

  29. Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res 2014 Dec 1; 104(3):412-22. doi: 10.1093/cvr/cvu222. PMID: 25341896. PMCID: PMC4296109

  30. Cheng M, Huang K, Zhou J, Tang Y-L, Zhao TC, Miller RJ, Kishore R, Losordo DW, and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015 Apr; 81:49-53. doi: 10.1016/j.yjmcc.2015.01.024. PMID: 25655934 PMCID: PMC4380859

  31. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015 Jun; 225:181-9. doi: 10.1530/JOE-14-0727. PMID: 25934704 PMCID: PMC4482239

  32. Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VNS, Benedict C, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Qin G, Houser SR, Koch WJ, Kishore R. Embryonic Stem Cell-derived Exosomes promote Endogenous Repair Mechanisms and Enhance Cardiac Function following Myocardial Infarction. Circ Res 2015 Jun 19; 117(1):52-64 doi: 10.1161/CIRCRESAHA.117.305990. PMID: 25904597 PMCID: PMC4482130

  33. Wang Y, Zhang L, Li Y, Chen L, Zhang X, Guo W, Zhang X, Qin G, He SH, Zimmerman A, Liu Y, Kim IM, Weintraub NL, Tang Y-L. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int’l J Cardiol 2015 Aug 1; 192:61-69. doi: 10.1016/j.ijcard.2015.05.020. PMID: 26000464 PMCID: PMC4469495

  34. Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T. Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells 2016 Jun; 34(6):1487-500. doi: 10.1002/stem.2301. PMID: 26824887

  35. Lizano P, Rashed E, Stoll S, Zhou N, Wen H, Hays TT, Qin G, Xie L-H, Depre C, Qiu H. The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo. Sci Rep 2017 Apr 20; 7:46324. doi: 10.1038/srep46324 PMID: 28425440 PMCID: PMC5397870

  36. Arnone B, Chen JY, Qin G. Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivoderived cardiac progenitor cells. PLoS ONE  2017 Jun 22;12(6): e0180096. doi: 10.1371/journal.pone.0180096. PMID: 28640894 PMCID: PMC5481004

  37. Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. Irisin Plays a Pivotal Role to Protect the Heart Against Ischemia and Reperfusion Injury. J Cell Physiol 2017 Dec; 232(12):3775-3785. doi: 10.1002/jcp.25857. PMID: 28181692 PMCID: PMC5550372

  38. Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Dong N-G, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G. E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells. Circ Res 2018 Mar 2; 122(5):701-11. doi: 10.1161/CIRCRESAHA.117.311814. PMID: 29358228 PMCID: PMC6021021

  39. Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, Hunter JD, Borovjagin AV, Walcott GP, Chen JY, Qin G, and Zhang J. Regenerative Potential of Neonatal Porcine Hearts. Circulation 2018 Dec 11; 138(24):2809-2816. doi: 10.1161/CIRCULATIONAHA.118.034886. PMID: 30030418. PMCID: PMC6301098

  40. Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, and Qin G Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun 2019 Feb 27; 10(1):959 doi: 10.1038/s41467-019-08895-7. PMID: 30814518. PMCID: PMC6393447

  41. Han S*, Xu Shiyue*, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Diyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P, Zhang C, Richard S, Qiu H, Zhang J, and Qin G. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol 2019 Dec; 137:82-92. doi: 10.1016/j.yjmcc.2019.10.003. PMID: 31639388 PMCID: PMC6889069

  42. Berry JL, Zhu W, Tang Y, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang H-T, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res 2019 Jan 4; 124(1):161-169. PMID: 30605412. PMCID: PMC6350935 DOI: 10.1161/CIRCRESAHA.118.314216 (Invited Review)

  43. Han D, Yang J, Zhang E, Liu Y, Boriboun C, Qiao A, Yu Y, Sun J, Xu S, Yang L, Yan W, Luo B, Lu D, Zhang C, Jie C, Mobley J, Zhang J, Qin G.. Analysis of mesenchymal stem cell proteome in situ in the infarcted heart. Theranostics 2020 Sep 14; 10(24):11324-38. doi: 10.7150/thno.47893. PMID: 33042285

  44. Zhang E, Liu Y, Han C, Fan C, Wang L, Chen W, Du Y, Han D, Arnone B, Xu S, Wei Y, Mobley J, Qin G. Visualization and identification of bioorthogonally-labeled exosome proteins following systemic administration in mice. Front Cell Dev Biol 2021 Apr 7; 9:657456. doi: 10.3389/fcell.2021.657456. PMID: 33898459 PMCID: PMC8058422

  45. Qiao A, Zhou J, Xu S, Ma W, Boriboun C, Kim T, Yan B, Deng J, Yang L, Zhang E, Song Y, Ma YC, Richard S, Zhang C, Qiu H, Habegger K, Zhang J, Qin G. Sam68 promotes hepatic gluconeogenesis via CRTC2. Nat Commun 2021 Jun 7; 12(1):3340. doi: 10.1038/s41467-021-23624-9. PMID: 34099657 PMCID: PMC8185084

  46. Yang L, Deng J, Ma W, Qiao A, Xu S, Yu Y, Boriboun C, Kang X, Han D, Ernst P, Zhou L, Shi J, Zhang E, Li TS, Qiu H, Nakagawa S, Blackshaw S, Zhang J, Qin G. Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure. Theranostics 2021 Jul 6; 11(16):7995-8007. doi: 10.7150/thno.50990. PMID: 34335976 PMCID: PMC8315059

  47. Qiao A, Ma W, Deng J, Zhou J, Han C, Zhang E, Boriboun C, Xu S, Zhang C, Jie C, Kim J, Habegger K, Qiu H, Zhao TC, Zhang J, Qin G. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure FASEB J 2021 Aug; 35(8):e21772. doi: 10.1096/fj.202100021R. PMID: 34252225 PMCID: PMC8285032

  48. Sun X, Zhou N, Ma B, Wu W, Stoll S, Lai L, Qin G, and Qiu H. Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model. Cells 2021 Oct 26; 10(11):2891. doi: 10.3390/cells10112891. PMID: 34831118 PMCID: PMC8616236

  49. Patil M, Saheera S, Dubey PK, Kahn-Krell A, Govindappa PK, Singh S, Tousif S, Zhang Q, Lal H, Zhang J, Qin G, Krishnamurthy P. Novel mechanisms of exosome-mediated phagocytosis of dead cells in injured heart. Circ Res 2021 Nov 12; 129(11):1006-1020. doi: 10.1161/CIRCRESAHA.120.317900. PMID: 34623174 PMCID: PMC8595793

  50. Qiao A, Ma W, Jiang Y, Han C, Yan B, Zhou J, Qin G. Hepatic Sam68 regulates systemic glucose homeostasis and insulin sensitivity. Int’l J Mol Sci 2022; 23(19): doi: 10.3390/ijms231911469. PMID:36232770

  51. Han C, Yang J, Sun J, and Qin G. Extracellular Vesicles in Cardiovascular Disease: Biological Functions and Therapeutic Implications. Pharmacol Ther 2022 May; 233:108025. doi: 10.1016/j.pharmthera.2021.108025. PMID: 34687770 (Invited Review)

  52. Han C and Qin G. Reporter systems for assessments of extracellular vesicle transfer. Front Cardiovasc Med 2022 Jun 1;9:922420. doi: 10.3389/fcvm.2022.922420. PMID: 35722089 PMCID: PMC9198260

  53. Han C, Yang J, Zhang E, Jiang Y, Qiao A, Du Y, Zhang Q, An J, Sun J, Wang M, Nguyen T, Lal H, Krishnamurthy P, Zhang J, Qin G. Metabolic labeling of cardiomyocyte-derived small extracellular-vesicle (sEV) miRNAs identifies miR-208a in cardiac regulation of lung gene expression. J Extracell Vesicles 2022 Oct;11(10):e12246. doi: 10.1002/jev2.12246. PMID: 36250966 PMCID: PMC9575700


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