裴国献从事骨科临床、教学和科研工作50年，是我国显微骨科领域具有重要国际影响力的主要领军人之一和数字骨科学的开拓者、奠基人。创建了我国严重肢体创伤救治理念与新技术体系，解决了极重度肢体创伤保肢的重大技术难题；在国际上最先开展大段骨缺损组织工程再生骨修复研究，被评为骨科权威杂志JBJS（美国版）2010年“骨科学最新研究进展”予以专题介绍；率先在亚洲成功开展异体肢体移植，“代表了当今世界同类手术最高水平，是世界肢体缺失重建领域里一个里程碑”，入选2000年度“中国医药科技十大新闻”；作为重大创新其多项理论和新技术体系被写入国际教科书和国际专著。
第一完成人获国家科技进步奖一等奖1项（2020）、二等奖1项（2002）、教育部自然科学一等奖1项、省军队一等奖3项和军队重大科技成果奖2项；主编专著22部，应Springer邀约主编的Microsurgical Orthopedics，被俄罗斯GEOTAR-Media出版社俄文出版发行（2021）。第一或通讯作者发表论文365 篇，其中SCI论文102篇。主持国家863、973、国家自然科学基金重点等项目23项，获发明专利17项。
裴国献任国务院学位委员会学科评议组成员、中华医学会显微外科学分会第七届主任委员、国际复合组织异体移植学会首任秘书长、《中华创伤骨科杂志》总编辑等职务。被授予国家级有突出贡献专家、国务院特殊津贴专家、全国首届中青年医学科技之星、全国百千万人才工程首批人选等国家级荣誉和称号。
再生骨科研究、智能与数字骨科
2019.11至今 南方科技大学医学院 讲席教授
2019.11至2024.1 南方科技大学医院 院长
2008.8至2019.10 第四军医大学（现空军军医大学）西京骨科医院、全军骨科研究所 院长、所长
1997.8至2008.7 第一军医大学（现南方医科大学）南方医院创伤骨科 主任
1986.6至1994.6 解放军第153医院全军显微外科中心 副主任、主任、副院长
1983.5至1986.5 解放军第89医院全军创伤外科中心 医师
1969.12至1983.4 中国人民解放军第136医院 医师
2023 何梁何利基金科学与技术进步奖
2020 国家科技进步奖一等奖（第一完成人）
2015 教育部自然科学奖一等奖(第一完成人)
2002 国家科技进步奖二等奖(第一完成人)
2021 第五届“白求恩式好医生”
1996 全国百千万人才工程首批人选
1994 国家级有突出贡献中青年科学技术专家
1994 国务院政府特殊津贴专家
1. Lei X, Miao S, Wang X, Gao Y, Wu H, Cheng P, Song Y, Bi L, Pei G. Microgroove Cues Guiding Fibrogenesis of Stem Cells via Intracellular Force. ACS Appl Mater Interfaces. 2023 Apr05;15(13):16380-16393.
2. Sun D, Liu J, Su X, Pei G. Fractional differential equation modeling of the HBV infection with time delay and logistic proliferation. Front Public Health. 2022 Nov 11;10:1036901.
3. Mingkui Shen, Lulu Wang, Li Feng, Chuangye Xu, Yi Gao, Sijing Li, Yulan Wu, Guoxian Pei. Cefazolin/BMP-2-Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects. Oxid Med Cell Longev. 2022 Sep 20;2022:8385456.
4. Zhao W, Guo Y, Xu C, Pei G, Basnet S, Pei Y, Su X. Distal Humerus Morphological Analysis of Chinese Individuals: A Statistical Shape Modeling Approach. Orthop Surg. 2022 Oct;14(10):2730-2740.
5. Mingkui Shen, Lulu Wang, Yi Gao, Li Feng, Chuangye Xu, Sijing Li, Xiaohu Wang, Yulan Wu, Yao Guo, Guoxian Pei. 3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects.Mater Today Bio. 2022 Aug 8;16:100382.
6. Sheng Miao, Jinru Zhou, Bin Liu, Xing Lei, Taoran Wang, Xiaotian Hao, Pengzhen Cheng, Hao Wu, Yue Song, Guoxian Pei, Long Bi. A 3D bioprinted nano-laponite hydrogel construct promotes osteogenesis by activating PI3K/AKT signaling pathway. Mater Today Bio. 2022 Jul 1;16:100342.
7. Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei. bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway. International Journal of Nanomedicine. 2022 Jun 7;17:2593-2608.
8. Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao,Long Wang, Guoxian Pei, and Liu Yang. Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion. Bioactive Materials. 2022 Jun,12:185-197.
9. Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX. Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro. Stem Cells Int. 2022 Jan 13;2022:4363632.
10. Yijun He, Wenhao Wang, Shaozhang Lin, Yixi Yang, Lizhi Song, Yihan Jing, Lihao Chen, Zaopeng He, Wei Li, Ao Xiong, Kelvin W.K. Yeung , Qi Zhao, Yuan Jiang, Zijie Li, Guoxian Pei, Zhi-Yong Zhang. Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation. Bioact Mater. 2022 May 27;20:164.
11. Zhang Xinxin, Jiang Xiaorui, Jiang Shan, Cai Xiyu, Yu Shengji, Pei Guoxian. Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells. Stem Cell Res Ther. 2021 Jul 7;12(1):382.
12. Liu B, Li J, Lei X, Miao S, Zhang S, Cheng P, Song Y, Wu H, Gao Y, Bi L, Pei G. Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model. RSC ADV 2020, 10(43): 25652-25661.
13. Liu B, Li J, Lei X, Cheng P, Song Y, Gao Y, Hu J, Wang C, Zhang S, Li D, Wu H, Sang H, Bi L, Pei G. 3D-bioprinted functional and biomimetic hydrogel scaffolds incorporated with nanosilicates to promote bone healing in rat calvarial defect model. Materials Science and Engineering: C 2020, 112: 110905.
14. Song Y, Wu H, Gao Y, Li J, Lin K, Liu B, Lei X, Cheng P, Zhang S, Wang Y,Sun J, Bi L, Pei G. Zinc Silicate/Nano-Hydroxyapatite/Collagen Scaffolds Promote Angiogenesis and Bone Regeneration via the p38 MAPK Pathway in Activated Monocytes. ACS APPL MATER INTER 2020, 12(14): 16058-16075.
15. Lei X, Wu H, Song Y, Liu B, Zhang S, Li J, Bi L, Pei G. Effects of cyclic fluid stress at different frequencies on behaviors of cells incubated on titanium alloy. BIOCHEM BIOPH RES CO .2020, 522(1): 100-106.
16. Wu H, Song Y, Li J, Lei X, Zhang S, Gao Y, Cheng P, Liu B, Miao S, Bi L, Yang L, Pei G. Blockade of adrenergic β‐receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo. CELL PROLIFERAT 2020, 53(1).
17. Lei X, Liu B, Wu H, Wu X, Wang X, Song Y, Zhang S, Li J, Bi L, Pei G. The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies. CELL ADHES MIGR 2020, 14(1): 12-23.
18. Li D, Cheng P, Jiang H, Cao T, Wang J, Gao Y, Lin Y, Wang C, Zhang S, Li J, Liu B, Song Y, Yang L, Pei G. Vascularization converts the lineage fate of bone mesenchymal stem cells to endothelial cells in tissue-engineered bone grafts by modulating FGF2-RhoA/ROCK signaling. CELL DEATH DIS 2018, 9(10).
19. Cheng P, Li D, Gao Y, Cao T, Jiang H, Wang J, Li J, Zhang S, Song Y, Liu B, Wang C, Yang L, Pei G. Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts. STEM CELL RES THER 2018, 9(1).
20. Jiang H, Cheng P, Li D, Li J, Wang J, Gao Y, Zhang S, Cao T, Wang C, Yang L, Pei G. Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering. J TISSUE ENG REGEN M 2018, 12(4): e2162-e2171.
21. Song Y, Lin K, He S, Wang C, Zhang S, Li D, Wang J, Cao T, Bi L, Pei G. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin. INT J NANOMED 2018, 13: 505-523.
22. Zhang S, Li J, Jiang H, Gao Y, Cheng P, Cao T, Li D, Wang J, Song Y, Liu B, Wu H, Wang C, Yang L, Pei G. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System. STEM CELLS INT 2018, 2018: 1-12.
