Older but Stronger: Development of Platinum-Based Antitumor Agents and Research Advances in Tumor Immunity

Liu，Jianing1; Cao，Yi1; Hu，Bin1; Li，Tao1; Zhang，Wei1; Zhang，Zhongze1; Gao，Jinhua1; Niu，Hanjing1; Ding，Tengli1; Wu，Jinzhong1; Chen，Yutong1; Zhang，Pengfei1; Ma，Ruijuan1; Su，Shihao1; Wang，Chaojie2; Wang，Peng George3; Ma，Jing1; Xie，Songqiang1

2023-04-01

10.3390/inorganics11040145

Inorganics   影响因子和分区

2304-6740

Platinum (Pt) drugs have developed rapidly in clinical applications because of their broad and highly effective antitumor effects. In recent years, with the rapid development of immunotherapy, Pt-based antitumor agents have gained new challenges and opportunities. Since the discovery of their pharmacological effects in immunotherapy and tumor microenvironment regulation, research into Pt drugs has progressed to multi-ligand and multi-functional Pt precursors and their own shortcomings have been further highlighted. With the development of antitumor immunotherapy and the rise of combination therapy, the development of Pt-based drugs has started to move in the direction of multi-targeting, nanocarrier modification, immunotherapy and photodynamic therapy. In this paper, we first overview the recent applications of Pt-based drugs in antitumor inorganic chemistry, with a focus on summarizing the application of Pt-based drugs and their precursors in the anticancer immune response. The paper also provides a reasonable outlook on the future development of Pt-based drugs from the chemical and immunological perspectives, relying on the existing content and problems of Pt-based drug development. On the basis of the gathered information, joint multidisciplinary programs on implementing comprehensive immune analyses for the future development of novel anticancer metal compounds should be initiated.

anticancer immune response metal drugs photodynamic and photosensitization therapy platinum-based antitumor drugs tumor microenvironment regulation

SCI

英语

其他

China Postdoctoral Science Foundation[2021M701089];Key Scientific Research Project of Colleges and Universities in Henan Province[222102310216];Key Scientific Research Project of Colleges and Universities in Henan Province[222102310402];Key Scientific Research Project of Colleges and Universities in Henan Province[22A350002];

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000977434700001

MDPI

2-s2.0-85153734464

Scopus

1.School of Pharmacy,Academy for Advanced Interdisciplinary Studies,Institute of Chemical Biology,Henan University,Kaifeng,475004,China
2.The Key Laboratory of Natural Medicine and Immuno-Engineering,Henan University,Kaifeng,475004,China
3.School of Medicine,The Southern University of Science and Technology,Shenzhen,518055,China

Liu，Jianing,Cao，Yi,Hu，Bin,et al. Older but Stronger: Development of Platinum-Based Antitumor Agents and Research Advances in Tumor Immunity[J]. Inorganics,2023,11(4).

Liu，Jianing.,Cao，Yi.,Hu，Bin.,Li，Tao.,Zhang，Wei.,...&Xie，Songqiang.(2023).Older but Stronger: Development of Platinum-Based Antitumor Agents and Research Advances in Tumor Immunity.Inorganics,11(4).

Liu，Jianing,et al."Older but Stronger: Development of Platinum-Based Antitumor Agents and Research Advances in Tumor Immunity".Inorganics 11.4(2023).