中文版 | English
题名

Macrophages in immunoregulation and therapeutics

作者
通讯作者Xiao, Gary Guishan; Rao, Lang; Duo, Yanhong
发表日期
2023-05-22
DOI
发表期刊
ISSN
2095-9907
EISSN
2059-3635
卷号8期号:1
摘要
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered. In addition, the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology. Moreover, they are an integral part of the tumor microenvironment, playing a part in the regulation of a wide variety of processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, and resistance to chemotherapeutic and checkpoint blockade immunotherapies. Herein, we discuss immune regulation in macrophage polarization and signaling, mechanical stresses and modulation, metabolic signaling pathways, mitochondrial and transcriptional, and epigenetic regulation. Furthermore, we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions. Moreover, we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis. Lastly, we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.
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语种
英语
重要成果
ESI热点 ; ESI高被引
学校署名
其他
资助项目
National Natural Science Foundation of China["81803183","82272779","82003036","82273236"] ; National Key R&D Program of China["2022YFF0710800","2022YFF0710802"] ; Natural Science Foundation of Sichuan province, China[2019YFS0230] ; Science and Technology Innovation Commission of Shenzhen[JCYJ20220530141608020] ; Natural Science Foundation of Guangdong province, China["2214050008970","2019A1515012079"] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515030182]
WOS研究方向
Biochemistry & Molecular Biology ; Cell Biology
WOS类目
Biochemistry & Molecular Biology ; Cell Biology
WOS记录号
WOS:000993248000002
出版者
Scopus记录号
2-s2.0-85160112173
来源库
Web of Science
引用统计
被引频次[WOS]:200
成果类型期刊论文
条目标识符http://kc.sustech.edu.cn/handle/2SGJ60CL/536320
专题南方科技大学第一附属医院
南方科技大学医学院
作者单位
1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Shenzhen Inst Resp Dis, Shenzhen 518020, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Crit Care Unit,Shenzhen Inst Resp Dis, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
4.City Hope Natl Med Ctr, Beckman Res Inst, Dept Canc Biol, Los Angeles, CA 91010 USA
5.Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Nanshan Hosp,Dept Lab Med, Shenzhen 518052, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Sch Med, Dept Resp, Shenzhen 518055, Peoples R China
7.Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian, Peoples R China
8.Shenzhen Bay Lab, Inst Biomed Hlth Technol & Engn, Shenzhen 518132, Peoples R China
9.Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden
第一作者单位南方科技大学第一附属医院
推荐引用方式
GB/T 7714
Chen, Shanze,Saeed, Abdullah F. U. H.,Liu, Quan,et al. Macrophages in immunoregulation and therapeutics[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1).
APA
Chen, Shanze.,Saeed, Abdullah F. U. H..,Liu, Quan.,Jiang, Qiong.,Xu, Haizhao.,...&Duo, Yanhong.(2023).Macrophages in immunoregulation and therapeutics.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1).
MLA
Chen, Shanze,et al."Macrophages in immunoregulation and therapeutics".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023).
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