题名 | Strategy of developing nucleic acid-based universal monkeypox vaccine candidates |
作者 | |
通讯作者 | He,Yunjiao; Wang,Peng George |
发表日期 | 2022-10-27
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DOI | |
发表期刊 | |
ISSN | 1664-3224
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EISSN | 1664-3224
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卷号 | 13 |
摘要 | Until May 2022, zoonotic infectious disease monkeypox (MPX) caused by the monkeypox virus (MPXV) was one of the forgotten viruses considered to be geographically limited in African countries even though few cases outside of Africa were identified. Central and West African countries are known to be endemic for MPXV. However, since the number of human MPX cases has rapidly increased outside of Africa the global interest in this virus has markedly grown. The majority of infected people with MPXV have never been vaccinated against smallpox virus. Noteworthily, the MPXV spreads fast in men who have sex with men (MSM). Preventive measures against MPXV are essential to be taken, indeed, vaccination is the key. Due to the antigenic similarities, the smallpox vaccine is efficient against MPXV. Nevertheless, there is no specific MPXV vaccine until now. Nucleic acid vaccines deserve special attention since the emergency approval of two messenger RNA (mRNA)-based coronavirus disease 2019 (COVID-19) vaccines in 2020. This milestone in vaccinology has opened a new platform for developing more mRNA- or DNA-based vaccines. Certainly, this type of vaccine has a number of advantages including time- and cost-effectiveness over conventional vaccines. The platform of nucleic acid-based vaccines gives humankind a huge opportunity. Ultimately, there is a strong need for developing a universal vaccine against MPXV. This review will shed the light on the strategies for developing nucleic acid vaccines against MPXV in a timely manner. Consequently, developing nucleic acid-based vaccines may alleviate the global threat against MPXV. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 第一
; 通讯
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资助项目 | Shenzhen Science and Technology Innovation Program[KQTD20200909113758004];
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WOS研究方向 | Immunology
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WOS类目 | Immunology
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WOS记录号 | WOS:000882749000001
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出版者 | |
Scopus记录号 | 2-s2.0-85141690091
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来源库 | Scopus
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引用统计 |
被引频次[WOS]:17
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成果类型 | 期刊论文 |
条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/411825 |
专题 | 南方科技大学医学院_药理学系 南方科技大学医学院 |
作者单位 | Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China |
第一作者单位 | 药理学系; 南方科技大学医学院 |
通讯作者单位 | 药理学系; 南方科技大学医学院 |
第一作者的第一单位 | 药理学系; 南方科技大学医学院 |
推荐引用方式 GB/T 7714 |
Papukashvili,Dimitri,Rcheulishvili,Nino,Liu,Cong,et al. Strategy of developing nucleic acid-based universal monkeypox vaccine candidates[J]. Frontiers in Immunology,2022,13.
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APA |
Papukashvili,Dimitri,Rcheulishvili,Nino,Liu,Cong,Wang,Xingyun,He,Yunjiao,&Wang,Peng George.(2022).Strategy of developing nucleic acid-based universal monkeypox vaccine candidates.Frontiers in Immunology,13.
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MLA |
Papukashvili,Dimitri,et al."Strategy of developing nucleic acid-based universal monkeypox vaccine candidates".Frontiers in Immunology 13(2022).
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条目包含的文件 | 条目无相关文件。 |
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