题名 | Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair |
作者 | |
通讯作者 | Wu, De-Cheng; Wang, Xing; Yu, Jia-Kuo |
发表日期 | 2022-10-17
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DOI | |
发表期刊 | |
EISSN | 2198-3844
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摘要 | The effectiveness of existing tissue-engineering cartilage (TEC) is known to be hampered by weak integration of biocompatibility, biodegradation, mechanical strength, and microenvironment supplies. The strategy of hydrogel-based TEC holds considerable promise in circumventing these problems. Herein, a non-toxic, biodegradable, and mechanically optimized double-network (DN) hydrogel consisting of polyethylene glycol (PEG) and kartogenin (KGN)-conjugated chitosan (CHI) is constructed using a simple soaking strategy. This PEG-CHI-KGN DN hydrogel possesses favorable architectures, suitable mechanics, remarkable cellular affinity, and sustained KGN release, which can facilitate the cartilage-specific genes expression and extracellular matrix secretion of peripheral blood-derived mesenchymal stem cells (PB-MSCs). Notably, after tracing the transplanted cells by detecting the rabbit sex-determining region Y-linked gene sequence, the allogeneic PB-MSCs are found to survive for even 3 months in the regenerated cartilage. Here, the long-term release of KGN is able to efficiently and persistently activate multiple genes and signaling pathways to promote the chondrogenesis, chondrocyte differentiation, and survival of PB-MSCs. Thus, the regenerated tissues exhibit well-matched histomorphology and biomechanical performance such as native cartilage. Consequently, it is believed this innovative work can expand the choice for developing the next generation of orthopedic implants in the loadbearing region of a living body. |
关键词 | |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
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重要成果 | ESI热点
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学校署名 | 通讯
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资助项目 | National Natural Science Foundation of China[
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WOS研究方向 | Chemistry
; Science & Technology - Other Topics
; Materials Science
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WOS类目 | Chemistry, Multidisciplinary
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
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WOS记录号 | WOS:000868844300001
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出版者 | |
来源库 | Web of Science
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引用统计 |
被引频次[WOS]:30
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成果类型 | 期刊论文 |
条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/406510 |
专题 | 工学院_生物医学工程系 |
作者单位 | 1.Peking Univ Third Hosp, Beijing Key Lab Sports Injuries, Dept Sports Med, Beijing 100191, Peoples R China 2.Peking Univ, Inst Sports Med, Beijing 100191, Peoples R China 3.Xiamen Univ, Dept Joint Surg & Sports Med, Zhongshan Hosp, Xiamen 361000, Peoples R China 4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 5.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
通讯作者单位 | 生物医学工程系 |
推荐引用方式 GB/T 7714 |
Chen, You-Rong,Yan, Xin,Yuan, Fu-Zhen,et al. Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair[J]. ADVANCED SCIENCE,2022.
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APA |
Chen, You-Rong.,Yan, Xin.,Yuan, Fu-Zhen.,Lin, Lin.,Wang, Shao-Jie.,...&Yu, Jia-Kuo.(2022).Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair.ADVANCED SCIENCE.
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MLA |
Chen, You-Rong,et al."Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair".ADVANCED SCIENCE (2022).
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