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题名

Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization

作者
通讯作者Lu, Xiong
发表日期
2017-03
DOI
发表期刊
ISSN
1936-0851
EISSN
1936-086X
卷号11期号:3页码:2561-2574
摘要
Adhesive hydrogels are attractive biomaterials for various applications, such as electronic skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both adequate adhesiveness and excellent mechanical properties remains a challenge. Inspired by the adhesion mechanism of mussels, we used a two-step process to develop an adhesive and tough polydopamine-clay-polyacrylamide (PDA-clay-PAM) hydrogel. Dopamine was intercalated into clay nanosheets and limitedly oxidized between the layers, resulting in PDA-intercalated clay nanosheets containing free catechol groups. Acrylamide monomers were then added and in situ polymerized to form the hydrogel. Unlike previous single-use adhesive hydrogels, our hydrogel showed repeatable and durable adhesiveness. It adhered directly on human skin without causing an inflammatory response and was easily removed without causing damage. The adhesiveness of this hydrogel was attributed to the presence of enough free catechol groups in the hydrogel, which were created by controlling the oxidation process of the PDA in the confined nanolayers of clay. This mimicked the adhesion mechanism of the mussels, which maintain a high concentration of catechol groups in the confined nanospace of their byssal plaque. The hydrogel also displayed superior toughness, which resulted from nanoreinforcement by clay and PDA-induced cooperative interactions with the hydrogel networks. Moreover, the hydrogel favored cell attachment and proliferation, owning to the high cell affinity of PDA. Rat full-thickness skin defect experiments demonstrated that the hydrogel was an excellent dressing. This free-standing, adhesive, tough, and biocompatible hydrogel may be more convenient for surgical applications than adhesives that involve in situ gelation and extra agents.
关键词
相关链接[来源记录]
收录类别
SCI ; EI
语种
英语
重要成果
NI期刊 ; NI论文 ; ESI高被引
学校署名
其他
资助项目
Fundamental Research Funds for the Central Universities[2682016CX075]
WOS研究方向
Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目
Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号
WOS:000398014900023
出版者
EI入藏号
20171403517884
EI主题词
Adhesion ; Amines ; Biocompatibility ; Biomechanics ; Gelation ; Molluscs ; Nanocomposites ; Nanosheets ; Nanostructured materials ; Neurophysiology ; Phenols
EI分类号
Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Solid State Physics:933 ; Materials Science:951
来源库
Web of Science
引用统计
被引频次[WOS]:750
成果类型期刊论文
条目标识符http://kc.sustech.edu.cn/handle/2SGJ60CL/29112
专题工学院_材料科学与工程系
作者单位
1.Southwest Jiaotong Univ, Minist Educ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.Sichuan Univ, Natl Engn Res Ctr Biomat, Genome Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
3.South China Univ Technol China, Sch Mat Sci & Engn, Dept Polymer Sci & Engn, Guangzhou 510641, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Civil & Environm Engn, Dept Chem & Biomol Engn, Mat Characterisat & Preparat Facil, Hong Kong, Hong Kong, Peoples R China
5.Southwest Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomass Mat, Sch Mat Sci & Engn, Mianyang 621010, Peoples R China
6.Flinders Univ S Australia, Ctr NanoScale Sci & Technol, Adelaide, SA 5042, Australia
7.Flinders Univ S Australia, Sch Comp Sci Engn & Math, Adelaide, SA 5042, Australia
8.South Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Han, Lu,Lu, Xiong,Liu, Kezhi,et al. Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization[J]. ACS Nano,2017,11(3):2561-2574.
APA
Han, Lu.,Lu, Xiong.,Liu, Kezhi.,Wang, Kefeng.,Fang, Liming.,...&Li, Zongjin.(2017).Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization.ACS Nano,11(3),2561-2574.
MLA
Han, Lu,et al."Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization".ACS Nano 11.3(2017):2561-2574.
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