Bactericidal and Cytotoxic Properties of Silver Nanoparticles

Liao, Chengzhu1; Li, Yuchao2; Tjong, Sie Chin3

2019-01-02

10.3390/ijms20020449

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   影响因子和分区

1422-0067

Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent antimicrobial properties. Accordingly, AgNPs have gained access into our daily life, and the inevitable human exposure to these nanoparticles has raised concerns about their potential hazards to the environment, health, and safety in recent years. From in vitro cell cultivation tests, AgNPs have been reported to be toxic to several human cell lines including human bronchial epithelial cells, human umbilical vein endothelial cells, red blood cells, human peripheral blood mononuclear cells, immortal human keratinocytes, liver cells, etc. AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes <= 10 nm. Furthermore, AgNPs can cross the brain blood barrier of mice through the circulation system on the basis of in vivo animal tests. AgNPs tend to accumulate in mice organs such as liver, spleen, kidney and brain following intravenous, intraperitoneal, and intratracheal routes of administration. In this respect, AgNPs are considered a double-edged sword that can eliminate microorganisms but induce cytotoxicity in mammalian cells. This article provides a state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings. Particular attention is paid to the bactericidal activity and cytotoxic effect in mammalian cells.

silver ion bacteria cytotoxicity cell culture membrane reactive oxygen species polymer nanocomposite food packaging wound dressing administration route

SCI

英语

ESI高被引

第一 ; 通讯

National Youth Science Foundation (China)[21703096] ; National Youth Science Foundation (China)[51407087]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:000459746500217

MDPI

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.Liaocheng Univ, Dept Mat Sci & Engn, Liaocheng 252000, Peoples R China
3.City Univ Hong Kong, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China

Liao, Chengzhu,Li, Yuchao,Tjong, Sie Chin. Bactericidal and Cytotoxic Properties of Silver Nanoparticles[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(2).

Liao, Chengzhu,Li, Yuchao,&Tjong, Sie Chin.(2019).Bactericidal and Cytotoxic Properties of Silver Nanoparticles.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(2).

Liao, Chengzhu,et al."Bactericidal and Cytotoxic Properties of Silver Nanoparticles".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.2(2019).