中文版 | English
题名

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

作者
通讯作者Zhou,Penghui; Zhang,Zheng
发表日期
2021
DOI
发表期刊
ISSN
0092-8674
EISSN
1097-4172
摘要

Analysis of the immune landscape in the lung and peripheral blood of COVID patients across different regions in China at the single-cell level documents the presence of viral RNAs in diverse cell types and highlights the potential contribution of megakaryocytes and monocyte subsets to cytokine storms.

关键词
相关链接[Scopus记录]
收录类别
语种
英语
重要成果
NI期刊 ; NI论文 ; ESI高被引
学校署名
通讯
WOS记录号
WOS:000636734000021
ESI学科分类
MOLECULAR BIOLOGY & GENETICS
Scopus记录号
2-s2.0-85101887279
来源库
Scopus
引用统计
被引频次[WOS]:469
成果类型期刊论文
条目标识符http://kc.sustech.edu.cn/handle/2SGJ60CL/221770
专题南方科技大学医学院
南方科技大学第二附属医院
作者单位
1.Biomedical Pioneering Innovation Center (BIOPIC),School of Life Sciences,Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Beijing Advanced Innovation Center for Genomics (ICG),Peking University,Beijing,100871,China
2.National Center for Liver Cancer,Second Military Medical University,Shanghai,200003,China
3.Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,200003,China
4.Ministry of Education (MOE) Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer,Second Military Medical University,Shanghai,200003,China
5.Bioland Laboratory (Guangzhou Regenerative Medicine and Health GuangDong Laboratory),Guangzhou,510005,China
6.Institute of Cancer Research,Shenzhen Bay Laboratory,Shenzhen,518132,China
7.Beijing Youan Hospital,Capital Medical University,Beijing,100069,China
8.Department of Oncology,The First Affiliated Hospital of USTC,Division of Molecular Medicine,Hefei National Laboratory for Physical Sciences at Microscale,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,230021,China
9.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518112,China
10.Center for Life Sciences,School of Life Science and Technology,Harbin Institute of Technology,Harbin,150080,China
11.State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Brain-Intelligence Technology (Shanghai),Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China
12.State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Sun Yat-sen University Cancer Center,Guangzhou,510060,China
13.Center for Bioinformatics,School of Life Science and Technology,Harbin Institute of Technology,China
14.State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin,300020,China
15.Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300020,China
16.Department of Infectious Diseases,Southwest Hospital,Army Medical University,Chongqing,400038,China
17.State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing,100875,China
18.Analytical Biosciences Beijing Limited,Beijing,100084,China
19.State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou,510060,China
20.Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou,510060,China
21.State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China
22.Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510530,China
23.Department of Infectious Disease,Shanghai Public Health Clinical Center,Shanghai,201052,China
24.Institute of Pathology and Southwest Cancer Center,Southwest Hospital,Army Medical University,Chongqing,400038,China
25.Cancer Center,Renmin Hospital of Wuhan University,Wuhan,430060,China
26.Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China
27.Shanghai Institute of Immunology,Department of Microbiology and Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China
28.Department of Infectious Diseases,Fifth Medical Center of Chinese PLA General Hospital,National Clinical Research Center for Infectious Diseases,Beijing,100039,China
29.Cancer Center,Huanggang Hospital of Traditional Chinese Medicine,Huanggang,438000,China
30.Center for Infection and Immunity,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai,519000,China
31.Department of Laboratory Medicine,Yuebei People's Hospital,Shantou University Medical College,Shaoguan,512025,China
32.Laboratory for Diagnosis of Clinical Microbiology and Infection,Medical Research Center,Shantou University Medical College,Shaoguan,512025,China
33.Center for Quantitative Biology,Peking University,Beijing,100871,China
34.Beijing Shijitan Hospital,Capital Medical University,Beijing,100038,China
35.Shanghai Public Health Clinical Center and Institute of Biomedical Sciences,Fudan University,Shanghai,201508,China
36.Yuebei People's Hospital,Shantou University Medical College,Shaoguan,512025,China
37.Intelligent Pathology Institute,Division of Life Sciences and Medicine,University of Science and Technology of China (USTC),Department of Pathology,the First Hospital Affiliated to USTC,Hefei,230036,China
38.Department of Pathology,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China
通讯作者单位南方科技大学医学院;  南方科技大学第二附属医院
推荐引用方式
GB/T 7714
Ren,Xianwen,Wen,Wen,Fan,Xiaoying,et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas[J]. CELL,2021.
APA
Ren,Xianwen.,Wen,Wen.,Fan,Xiaoying.,Hou,Wenhong.,Su,Bin.,...&Zhang,Zemin.(2021).COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.CELL.
MLA
Ren,Xianwen,et al."COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas".CELL (2021).
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