题名 | Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China |
作者 | |
通讯作者 | Chen, Jun; Xu, Lin |
发表日期 | 2020-07
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DOI | |
发表期刊 | |
ISSN | 0149-5992
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EISSN | 1935-5548
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卷号 | 43期号:7页码:1392-1398 |
摘要 | OBJECTIVE Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association of obesity with the severity of coronavirus disease 2019 (COVID-19) is unclear. We examined this association using data from the only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS A total of 383 consecutively hospitalized patients with COVID-19 admitted from 11 January 2020 to 16 February 2020 and followed until 26 March 2020 at the Third People's Hospital of Shenzhen were included. Underweight was defined as a BMI <18.5 kg/m(2), normal weight as 18.5-23.9 kg/m(2), overweight as 24.0-27.9 kg/m(2), and obesity as >= 28 kg/m(2). RESULTS Of the 383 patients, 53.1% were normal weight, 4.2% were underweight, 32.0% were overweight, and 10.7% were obese at admission. Obese patients tended to have symptoms of cough (P= 0.03) and fever (P= 0.06) compared with patients who were not obese. Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99-3.43,P= 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40-2.86,P= 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease, and cancer, and drug used for treatment. Additionally, after similar adjustment, men who were obese versus those who were normal weight were at increased odds of developing severe COVID-19 (OR 5.66, 95% CI 1.80-17.75,P= 0.003). CONCLUSIONS In this study, obese patients had increased odds of progressing to severe COVID-19. As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obese patients, who should be carefully managed with prompt and aggressive treatment. |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
|
重要成果 | ESI高被引
; NI期刊
|
学校署名 | 第一
; 通讯
|
资助项目 | Sanming Project of Medicine in Shenzhen[SZSM201412003][SZSM201512005]
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WOS研究方向 | Endocrinology & Metabolism
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WOS类目 | Endocrinology & Metabolism
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WOS记录号 | WOS:000543534300010
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出版者 | |
ESI学科分类 | CLINICAL MEDICINE
|
来源库 | Web of Science
|
引用统计 |
被引频次[WOS]:431
|
成果类型 | 期刊论文 |
条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/140678 |
专题 | 南方科技大学第二附属医院 |
作者单位 | 1.Southern Univ Sci & Technol, Affiliated Hosp 2, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China 2.Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China |
第一作者单位 | 南方科技大学第二附属医院 |
通讯作者单位 | 南方科技大学第二附属医院 |
第一作者的第一单位 | 南方科技大学第二附属医院 |
推荐引用方式 GB/T 7714 |
Cai, Qingxian,Chen, Fengjuan,Wang, Tao,et al. Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China[J]. DIABETES CARE,2020,43(7):1392-1398.
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APA |
Cai, Qingxian.,Chen, Fengjuan.,Wang, Tao.,Luo, Fang.,Liu, Xiaohui.,...&Xu, Lin.(2020).Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China.DIABETES CARE,43(7),1392-1398.
|
MLA |
Cai, Qingxian,et al."Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China".DIABETES CARE 43.7(2020):1392-1398.
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