中文版 | English
题名

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

作者
通讯作者Liu, Yingxia; Jiang, Chengyu; Liu, Lei
发表日期
2020-02-09
DOI
发表期刊
ISSN
1674-7305
EISSN
1869-1889
卷号63期号:3页码:364-374
摘要

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

关键词
相关链接[来源记录]
收录类别
语种
英语
重要成果
ESI高被引
学校署名
第一 ; 通讯
资助项目
China Postdoctoral Science Foundation[2019T120147]
WOS研究方向
Life Sciences & Biomedicine - Other Topics
WOS类目
Biology
WOS记录号
WOS:000518376300004
出版者
来源库
Web of Science
引用统计
被引频次[WOS]:1351
成果类型期刊论文
条目标识符http://kc.sustech.edu.cn/handle/2SGJ60CL/104583
专题南方科技大学第一附属医院
作者单位
1.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis,Shenzhen Peoples, Natl Clin Res Ctr Infect Dis,Hosp Affiliated 1, Shenzhen 518112, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
4.Chinese Acad Med Sci, Dept Biochem, Peking Union Med Coll, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
5.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
6.Peking Union Med Coll Hosp, Emergence Dept, Beijing 100731, Peoples R China
第一作者单位南方科技大学第一附属医院
通讯作者单位南方科技大学第一附属医院
第一作者的第一单位南方科技大学第一附属医院
推荐引用方式
GB/T 7714
Liu, Yingxia,Yang, Yang,Zhang, Cong,et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury[J]. Science China-Life Sciences,2020,63(3):364-374.
APA
Liu, Yingxia.,Yang, Yang.,Zhang, Cong.,Huang, Fengming.,Wang, Fuxiang.,...&Liu, Lei.(2020).Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.Science China-Life Sciences,63(3),364-374.
MLA
Liu, Yingxia,et al."Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury".Science China-Life Sciences 63.3(2020):364-374.
条目包含的文件
条目无相关文件。
个性服务
原文链接
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
导出为Excel格式
导出为Csv格式
Altmetrics Score
谷歌学术
谷歌学术中相似的文章
[Liu, Yingxia]的文章
[Yang, Yang]的文章
[Zhang, Cong]的文章
百度学术
百度学术中相似的文章
[Liu, Yingxia]的文章
[Yang, Yang]的文章
[Zhang, Cong]的文章
必应学术
必应学术中相似的文章
[Liu, Yingxia]的文章
[Yang, Yang]的文章
[Zhang, Cong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
[发表评论/异议/意见]
暂无评论

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。

Baidu
map