Self-introduction：

Dr. Zhengyu Liang received his bachelor’s degree (bioinformatics) from Huazhong University of Science and Technology in 2012 and Ph.D. degree (Biology) from Tsinghua University in 2018, followed by postdoctoral research at University of California San Diego. In 2023, Zhengyu joined SUSTech as a tenure-track assistant professor and principal investigator. For a long time, Zhengyu mainly focuses on functional genomics and ecDNA biology in tumor using both benchwork and bioinformatics strategies. Previous work has been published in top journals including Cell, Circulation, Nature Communication, Cell Reports etc.

Research Interests：

◆ 3D genomic research on new technology and application

◆ Mechanism studies of transcriptional regulation

◆ RNA metabolism in functional genomics

◆ ecDNA biology in tumor

Professional Experience：

◆ 2023.4 – now, SUSTech, Department of Systems Biology, Assistant Professor

◆ 2018.9 – 2023.4, UC San Diego, Department of Cellular & Molecular Medicine, Postdoc

Educational Background：

◆ 2012.9 – 2018.1, Tsinghua University, Biology, Ph.D.

◆ 2008.9 – 2012.6, Huazhong University of Science & Technology, Bioinformatics, Bachelor

Selected Publication：

◆ Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X. (2019). Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell 178, 107-121. e118.

◆ Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y. (2017). BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions. Nature communications 8, 1622.

◆ Liang, Z., and Fu, X.-D. (2021). 3D genome encoded by LINE and SINE repeats. Cell Research 31, 603-604.

◆ Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J. (2022). PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle. Circulation 145, 586-602.

◆ Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W. (2022). CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 39, 110626.

◆ Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550-556.

◆ Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180, 1212-1227. e1214.

◆ Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S. (2022). Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy. Cancer discovery 12, 502-521.

◆ Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S. (2022). Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy. Circulation 146, 1028-1031.