Basic Introduction:

Dr. Bintian Zhang received his B.Sc. and Ph.D. degrees in Environmental Science from the Nankai University and the Chinese Academy of Sciences, respectively. Before joining SUSTech, he was an associate research scientist at the Biodesign Institute of Arizona State University. His research focuses on the detection of low-concentration environmental pollutants, toxicity screening of pollutants and molecular toxicology study, based on highly sensitive bioanalytical methods and biosensors. He holds six PCT, US and Chinese patents. He has published more than 30 peer-reviewed papers, including first-author papers in PNAS, JACS, ACS Nano, Nano Lett, Anal. Chem. etc. He has made breakthrough progresses on protein conductance, which was reported by over 10 international media such as AAAS and had generated significant academic impact.

Professional Experience:

2022.12 - present, Associate Professor (as PI), Southern University of Science and Technology

2021.09 - 2022.11, Assistant Professor (as PI), Southern University of Science and Technology

2016.10 - 2021.06, Associate Research Scientist, Arizona State University

2015.01 - 2016.10, Associate Professor, Chinese Academy of Sciences

2012.07 - 2014.12, Assistant Professor, Chinese Academy of Sciences

Education:

2007 - 2012, Ph.D. in Environmental Science, Chinese Academy of Sciences

2003 - 2007, B.S. in Environmental Science, Nankai University

Awards and Honors:

2021, Valued Contribution Award from ACS Publications, ACS

2020, Outstanding Reviewer Award 2020 by the Journal of “Sensors & Actuators: B. Chemical”

2019, Technology Transfer Innovation Award, ASU

2012, Best Poster Award, The 28th Chinese Chemical Society Congress

2009 - 2011, Graduate Scholarship, Chinese Academy of Sciences

2008 - 2010, Outstanding Graduate Student Awards, Chinese Academy of Sciences

2006, National Scholarship, Nankai University

Selected funded projects:

1. Investigation of the interactions between endocrine-disrupting chemicals and proteins based on single-molecule protein conductance, National Science Foundation of China, 2023-2026 (As PI)

2. Photoelectrochemical sensors based on the molecular imprinting technique for the detection of phenolic endocrine-disrupting chemicals, National Science Foundation of China, 2014-2016 (As PI)

3. Photoelectrochemical sensors based on ZnO nanoflower, Fujian Science Foundation, 2014-2016 (As PI)

Research Interests:

1、Environmental analytical chemistry

2、Bioanalytical chemistry

3、Environmental monitoring and molecular toxicology study

4、Biosensors and analytical instrument development

Teaching:

ESE336 - Environmental Analytical Chemistry (Undergraduate)

ESE5096 - Environmental Bioanalytical Chemistry (Graduate)

Published Works:

Publications (#: equal contribution; *: corresponding author) 

1. Hu, Q., Ren, G., Ye, J., Zhang, B.*, Rensing, C. & Zhou, S*. Hygroelectric-photovoltaic coupling generator using self-assembled bio-nano hybrids. Chemical Engineering Journal 452, 139169, (2023).

2. Tang, L., Yi, L., Jiang, T., Ren, R., Nadappuram, B. P., Zhang, B., Wu, J., Liu, X., Lindsay, S., Edel, J. B. & Ivanov, A. P. Measuring conductance switching in single proteins using quantum tunneling. Science Advances 8, eabm8149, (2022).

3. Hu, Q., Ma, Y., Ren, G., Zhang, B. & Zhou, S. Water evaporation–induced electricity with Geobacter sulfurreducens biofilms. Science Advances 8, eabm8047, (2022).

4. Zhang, B.#, Ryan, E.#, Wang, X., Song, W. & Lindsay, S. Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins. ACS Nano 16, 1671-1680, (2022).

5. Zhang, B.#, Ryan, E.#, Wang, X. & Lindsay, S. Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency. J. Am. Chem. Soc. 143, 15139-15144, (2021).

6. Ren, G., Wang, Z., Zhang, B., Liu, X., Ye, J., Hu, Q. & Zhou, S. A facile and sustainable hygroelectric generator using whole-cell Geobacter sulfurreducens. Nano Energy 89, 1-8, (2021).

7. Zhang, B., Song, W., Brown, J., Nemanich, R. & Lindsay, S. Electronic conductance resonance in non-redox-active proteins. J. Am. Chem. Soc. 142, 6432-6438, (2020).

8. Zhang, B. & Lindsay, S. Electronic decay length in a protein molecule. Nano Lett. 19, 4017-4022, (2019).

9. Zhang, B.#, Deng, H.#, Mukherjee, S., Song, W., Wang, X. & Lindsay, S. Engineering an enzyme for direct electrical monitoring of activity. ACS nano 14, 1360-1368, (2019).

10. Zhang, B., Song, W., Pang, P., Lai, H., Chen, Q., Zhang, P. & Lindsay, S. Role of contacts in long-range protein conductance. Proceedings of the National Academy of Sciences 116, 5886-5891, (2019).

11. Xiao, B., Liang, F., Liu, S., Im, J., Li, Y., Liu, J., Zhang, B., Zhou, J., He, J. & Chang, S. Cucurbituril mediated single molecule detection and identification via recognition tunneling. Nanotechnology 29, 365501, (2018).

12. Zhang, B.#, Song, W.#, Pang, P., Zhao, Y., Zhang, P., Csabai, I., Vattay, G. & Lindsay, S. Observation of giant conductance fluctuations in a protein. Nano futures 1, 035002, (2017).

13. Zhang, B., Lu, L., Huang, F. & Lin, Z. [Ru (bpy) 3] 2+-mediated photoelectrochemical detection of bisphenol A on a molecularly imprinted polypyrrole modified SnO2 electrode. Anal. Chim. Acta 887, 59-66, (2015).

14. Wu, Y., Yang, X., Zhang, B. & Guo, L.-H. An electrochemiluminescence biosensor for 8-oxo-7, 8-dihydro-2′-deoxyguanosine quantification and DNA repair enzyme activity analysis using a novel bifunctional probe. Biosens. Bioelectron. 69, 235-240, (2015).

15. Wang, C., Zhang, Y., Guan, M., Cui, L., Ding, K., Zhang, B., Lin, Z., Huang, F. & Zeng, Y. Specific detection of mercury (II) irons using AlGaAs/InGaAs high electron mobility transistors. J. Cryst. Growth 425, 381-384, (2015).

16. Lu, L., Yue, X., Lin, F., Huang, F., Zhang, B.*& Lin, Z.* Template-synthesized ultra-thin molecularly imprinted polymers membrane for the selective preconcentration of dyes. J. Mater. Chem. A 3, 10959-10968, (2015).

17. Zhang, B., Lu, L., Hu, Q., Huang, F. & Lin, Z. ZnO nanoflower-based photoelectrochemical DNAzyme sensor for the detection of Pb2+. Biosens. Bioelectron. 56, 243-249, (2014).

18. Ding, K., Wang, C., Zhang, B., Zhang, Y., Guan, M., Cui, L., Zhang, Y., Zeng, Y., Lin, Z. & Huang, F. Specific detection of alpha-fetoprotein using AlGaAs/GaAs high electron mobility transistors. IEEE Electron Device Lett. 35, 333-335, (2014).

19. Wu, Y., Zhang, B. & Guo, L.-H. Label-free and selective photoelectrochemical detection of chemical DNA methylation damage using DNA repair enzymes. Anal. Chem. 85, 6908-6914, (2013).

20. Ren, X.-M., Guo, L.-H., Gao, Y., Zhang, B.-T. & Wan, B. Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination. Toxicol. Appl. Pharmacol. 268, 256-263, (2013).

21. Li, M.-J., Wu, Y.-P., Zhang, B.-T. & Guo, L.-H. Detection and application of DNA abasic sites. Chin. J. Anal. Chem. 41, 965-972, (2013).

22. Zhang, B., Guo, L.-H. & Greenberg, M. M. Quantification of 8-OxodGuo Lesions in Double-Stranded DNA Using a Photoelectrochemical DNA Sensor. Anal. Chem. 84, 6048-6053, (2012).

23. Zhang, B. & Guo, L.-H. in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.   (AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA).

24. Zhang, B. & Guo, L.-H. Highly sensitive and selective photoelectrochemical DNA sensor for the detection of Hg2+ in aqueous solutions. Biosens. Bioelectron. 37, 112-115, (2012).

25. Zhang, B., Du, X., Jia, S., He, J. & Guo, L. Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor. Science China Chemistry 54, 1260, (2011).

Patents Granted:

1. “Method for electronic detection and quantification of antibodies”, Stuart Lindsay, Bintian Zhang, WO2019217600A1, Nov. 14, 2021 (US/PCT)

2. “Bioelectronic circuits, systems and methods for preparing and using them”, Stuart Lindsay, Bintian Zhang, Hanqing Deng, WO2020160300A3, Sep. 10, 2020 (US/PCT)

3. “Direct electrical readout of nucleic acid sequences”, Stuart Lindsay, Bintian Zhang, Hanqing Deng, WO2020257654A1, Dec. 24, 2020 (US/PCT)

4. “Methods for sequencing biopolymers”, Stuart Lindsay, Eathen Ryan, Bintian Zhang, Xu Wang, US20220389502A1, Jun. 3, 2022 (US)