Self-introduction

Dr Tian Xie obtained her Bachelor degree from University of Science and Technology of China in 2010. She got her Ph.D. degree from Tsinghua University in 2015. Then she did postdoc training in MRC Laboratory of Molecular Biology and UT Southwestern Medical Center between 2015 and 2019. She joined SUSTech in 2019 and is currently a research associate professor in the School of Life Sciences.

Research Interests：

◆Lipid metabolism

◆Biochemistry

◆Structural biology

Professional Experience：

◆ 2019 - present   Southern University of Science and Technology, Research associate professor

◆ 2017 - 2019       UT Southwestern Medical Center, Postdoc

◆ 2015 - 2017       MRC Laboratory of Molecular Biology, Postdoc

Educational Background：

◆ 2010 - 2015       Tsinghua University, School of Life Sciences, Ph.D.

◆ 2006 - 2010       University of Science and Technology of China, School of Life Sciences, B.S.

Honors & Awards：

◆ Shenzhen Peacock Talent Program

Selected Publication：

◆ Xie T*, Fang Q*, Zhang Z, Wang Y, Dong F, Gong X#. Structure and mechanism of a eukaryotic ceramide synthase complex. The EMBO Journal. 2023 Dec 11;42(24):e114889.

◆ Xie T*, Liu P*, Wu X, Yue J, Dong F, Zhang Z, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg BW#, Gong X#. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nature Communications. 2023 Jun 13;(14)1:3475.

◆ Liu P*, Xie T*, Wu X, Han G,  Gupta SD, Zhang Z, Yue J, Dong F, Gable K, Niranjanakumari S, Li W, Wang L, Liu W, Yao R, Cahoon EB, Dunn TM, Gong X#.  Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Science Advances. 2023 Mar 29; 9(13):eadg0728

◆ Xie T*，Zhang Z*，Yue J*，Fang Q，Gong X#. Cryo-EM structures of the human surfactant lipid transporter ABCA3. Science Advances. 2022 Apr 8; 8(14): eabn3727.

◆ Xie T*, Zhang Z*, Fang Q, Du B, Gong X#. Structural basis of substrate recognition and translocation by human ABCA4.  Nature Communications. 2021 Jun 22;12(1):3853.

◆ Li S*, Xie T*, Liu P*, Wang L, Gong X#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex.  Nature Structural & Molecular Biology. 2021 Feb 8;28 (3), 249-257.