Guoxian Pei, Chair Professor of Medicine, Southern University of Science and Technology, Dean of the Southern University of Science and Technology Hospital, doctoral tutor. Enjoy special government subsidies of the State Council. Has won the "national first young and middle-aged medical science and technology star", "national outstanding contribution of young and middle-aged science and technology experts", "national 100 million talent project" the first batch of candidates and other titles. In 2000 was named "Army Science and Technology Venus", in 2001 was identified by the General Logistics Department as "the reserve candidate of the General Post-Academy", in 2002 by the "Military Professional and Technical Significant Contribution Award", in 2003 by the "Army Outstanding Talents Category I Post Allowance". Won the second prize of national scientific and technological progress, 14 military scientific research achievements (of which 1 first prize, 4 second prize), for the "95" military major medical achievements award winners. As a well-known expert in orthopaedic and tissue engineering in China, this paper puts forward bone tissue engineering research and puts forward a new theory of the simultaneous construction of vascular, nerve and tissue engineering tissue and organs in the world.

As a well-known expert in orthopaedic and tissue engineering research in China, Professor Pei Guoxuan has created a number of new theories and technologies for physical serious battle and trauma treatment, and has formed a more complete theoretical and clinical treatment system, and has achieved a number of innovative achievements with international advanced, Asian initiative and domestic leading. Internationally, the first report of the success of separation and replanting of limbs at the same time, the first "double-bridge flap transplant" repair technology for severe trauma of the lower limbs to avoid amputation, the creation of asia's first allogeneic limb transplant, successfully carried out the first and second cases (3rd and 4rd in the world) allogeneic hand transplantation in Asia, was named the "Top Ten News of Chinese Medicine Science and Technology" in 2000. For one of the pioneers of bone tissue engineering research in China, a new theory of simultaneous construction of vascular, neuroand tissue engineered tissues and organs has been put forward in the world, and the tissue engineered bone tissue with blood vessels has been successfully constructed in large animals, which has entered the pre-clinical stage. Founded the Chinese Medical Association series of journals - "Chinese Journal of Trauma Orthopaedics." The editor-in-chief of 8 monographs, published more than 300 articles at home and abroad, presided over the national 863 major special projects, the national 973 project, the National Natural Science Foundation, the army outstanding young and middle-aged talent fund, the military key research fund and other 16 funds to support a total of 8 million yuan. As the chief scientist of Guangdong Organizational Engineering Research and Development Center. To the first completed person won a total of 17 awards for various scientific and technological achievements, including the second prize of national scientific and technological progress 1, the provincial (military) first prize for scientific and technological achievements 3, the army's major scientific and technological achievements award 2, the national invention patent 1. Has been awarded the "national first young and middle-aged medical science and technology star", "national outstanding contribution of young and middle-aged science and technology experts", "the first batch of 100 million talent project candidates" and other honorary titles. In 2000, he was awarded the highest award of "Army Science and Technology Gold Star" by the General Logistics Department, the first batch of "Reserve Candidates for General Post-Academy" by the General Logistics Department in 2001, the "Army Professional and Technical Contribution Award" by the Army's Top Talent Award in 2002, the "Army Talent skilled persons Class I Post Allowance" in 2003, and the 2004 Award in 2004. Guangdong Province Famous Medical Engineering Project (the first overall score of the province); In September 2007, it obtained the key project of the National Natural Science Foundation of China (NSFC) -Guangdong Province Joint Fund, "Research on key technologies of tissue engineering bone and vascular, neurogenesis and related issues".

Publications

1. Lei X, Miao S, Wang X, Gao Y, Wu H, Cheng P, Song Y, Bi L, Pei G. Microgroove Cues Guiding Fibrogenesis of Stem Cells via Intracellular Force. ACS Appl Mater Interfaces. 2023 Apr05;15(13):16380-16393.

2. Sun D, Liu J, Su X, Pei G. Fractional differential equation modeling of the HBV infection with time delay and logistic proliferation. Front Public Health. 2022 Nov 11;10:1036901.

3. Mingkui Shen, Lulu Wang, Li Feng, Chuangye Xu, Yi Gao, Sijing Li, Yulan Wu, Guoxian Pei. Cefazolin/BMP-2-Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects. Oxid Med Cell Longev. 2022 Sep 20;2022:8385456.

4. Zhao W, Guo Y, Xu C, Pei G, Basnet S, Pei Y, Su X. Distal Humerus Morphological Analysis of Chinese Individuals: A Statistical Shape Modeling Approach. Orthop Surg. 2022 Oct;14(10):2730-2740.

5. Mingkui Shen, Lulu Wang, Yi Gao, Li Feng, Chuangye Xu, Sijing Li, Xiaohu Wang, Yulan Wu, Yao Guo, Guoxian Pei. 3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects.Mater Today Bio. 2022 Aug 8;16:100382.

6. Sheng Miao, Jinru Zhou, Bin Liu, Xing Lei, Taoran Wang, Xiaotian Hao, Pengzhen Cheng, Hao Wu, Yue Song, Guoxian Pei, Long Bi. A 3D bioprinted nano-laponite hydrogel construct promotes osteogenesis by activating PI3K/AKT signaling pathway. Mater Today Bio. 2022 Jul 1;16:100342.

7. Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei. bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway. International Journal of Nanomedicine. 2022 Jun 7;17:2593-2608.

8. Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao,Long Wang, Guoxian Pei, and Liu Yang. Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion. Bioactive Materials. 2022 Jun,12:185-197.

9. Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX. Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro. Stem Cells Int. 2022 Jan 13;2022:4363632.

10. Yijun He, Wenhao Wang, Shaozhang Lin, Yixi Yang, Lizhi Song, Yihan Jing, Lihao Chen, Zaopeng He, Wei Li, Ao Xiong, Kelvin W.K. Yeung , Qi Zhao, Yuan Jiang, Zijie Li, Guoxian Pei, Zhi-Yong Zhang. Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation. Bioact Mater. 2022 May 27;20:164.

11. Zhang Xinxin, Jiang Xiaorui, Jiang Shan, Cai Xiyu, Yu Shengji, Pei Guoxian. Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells. Stem Cell Res Ther. 2021 Jul 7;12(1):382.

12. Liu B, Li J, Lei X, Miao S, Zhang S, Cheng P, Song Y, Wu H, Gao Y, Bi L, Pei G. Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model. RSC ADV 2020, 10(43): 25652-25661.

13. Liu B, Li J, Lei X, Cheng P, Song Y, Gao Y, Hu J, Wang C, Zhang S, Li D, Wu H, Sang H, Bi L, Pei G. 3D-bioprinted functional and biomimetic hydrogel scaffolds incorporated with nanosilicates to promote bone healing in rat calvarial defect model. Materials Science and Engineering: C 2020, 112: 110905.

14. Song Y, Wu H, Gao Y, Li J, Lin K, Liu B, Lei X, Cheng P, Zhang S, Wang Y,Sun J, Bi L, Pei G. Zinc Silicate/Nano-Hydroxyapatite/Collagen Scaffolds Promote Angiogenesis and Bone Regeneration via the p38 MAPK Pathway in Activated Monocytes. ACS APPL MATER INTER 2020, 12(14): 16058-16075.

15. Lei X, Wu H, Song Y, Liu B, Zhang S, Li J, Bi L, Pei G. Effects of cyclic fluid stress at different frequencies on behaviors of cells incubated on titanium alloy. BIOCHEM BIOPH RES CO .2020, 522(1): 100-106.

16. Wu H, Song Y, Li J, Lei X, Zhang S, Gao Y, Cheng P, Liu B, Miao S, Bi L, Yang L, Pei G. Blockade of adrenergic β‐receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo. CELL PROLIFERAT 2020, 53(1).

17. Lei X, Liu B, Wu H, Wu X, Wang X, Song Y, Zhang S, Li J, Bi L, Pei G. The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies. CELL ADHES MIGR 2020, 14(1): 12-23.

18. Li D, Cheng P, Jiang H, Cao T, Wang J, Gao Y, Lin Y, Wang C, Zhang S, Li J, Liu B, Song Y, Yang L, Pei G. Vascularization converts the lineage fate of bone mesenchymal stem cells to endothelial cells in tissue-engineered bone grafts by modulating FGF2-RhoA/ROCK signaling. CELL DEATH DIS 2018, 9(10).

19. Cheng P, Li D, Gao Y, Cao T, Jiang H, Wang J, Li J, Zhang S, Song Y, Liu B, Wang C, Yang L, Pei G. Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts. STEM CELL RES THER 2018, 9(1).

20. Jiang H, Cheng P, Li D, Li J, Wang J, Gao Y, Zhang S, Cao T, Wang C, Yang L, Pei G. Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering. J TISSUE ENG REGEN M 2018, 12(4): e2162-e2171.

21. Song Y, Lin K, He S, Wang C, Zhang S, Li D, Wang J, Cao T, Bi L, Pei G. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin. INT J NANOMED 2018, 13: 505-523.

22. Zhang S, Li J, Jiang H, Gao Y, Cheng P, Cao T, Li D, Wang J, Song Y, Liu B, Wu H, Wang C, Yang L, Pei G. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System. STEM CELLS INT 2018, 2018: 1-12.