LI Yiming
Research Professor
Innovation Center for Biopharma
E-mail: liym3@sustech.edu.cn

Research Fields

Technology development for recombinant protein production, protein purification, drug protein quality and stability analyses; research and development of biocatalysts for drug and chemical intermediate synthesis.  Technology development for enzyme immobilization.

Educational Background 

Ph.D. in Biochemistry: 1994.08  – 1997.11.,   Department of Biochemistry, Uppsala University, Uppsala, Sweden.

Ph.D, in Zoology: 1985.03. – 1988. 08., Department of Biology. Zhongshan University, Guangzhou, China.

Master of Science: 1982.03. – 1985.02., Department of Biology, Zhongshan University, Guangzhou, China.

Bachelor of Science: 1978.03. – 1982.01., Department of Biology, Zhongshan University, Guangzhou, China.

Working Experience

2018.10. – Present: Research Professor, Southern University of Science and Technology, Shenzhen, China.

2016.09. – 2018.09.: Chief Scientific Officer, Biosolutions-Plus, USA.

2009.09 – 2016.08.: Scientist II, Medimmune LLC. (AstraZeneca), USA.

2002.05 – 2009.08.: Scientist, Senior Scientist, Human Genome Sciences, Inc. USA.

1998.08 – 2002.04.: Postdoctoral Research Fellow, Harvard Medical School, USA.

1997.12. – 1998.07.: Postdoctoral Researcher, Uppsala University, Sweden.

1990.01, - 1994.07.: Postdoctoral Researcher, Uppsala University and Karolinska Institute, Sweden.

1988.09. – 1989.12.: Engineer, Shenzhen Science and Technology Development and Exchange Center.

Papers and Publications

1. Li YM, Polozova A, Gruia F, and Feng J. (2014) Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores. Analytical Chemistry, 86: 6850-6857.

2. Li YM, Stafford W, Hesselberg M, Hayes D, Wu Z. Byrne M. (2011) Characterization of the self-association of human interferon-α2b, albinterferon-α2b, and pegasys. Journal of Pharmaceutical Sciences. 101-1: 68–80

3. Irwin N, Li YM, O’toole JE and Benowitz, L. (2006) Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Natl. Acad. Sci. USA 103(48): 18320-18325.

4. Li YM, Irwin N, Yin YQ, Lanser M and Benowitz L. (2003) Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP. J. Neurosci. 23 (21): 7830-7838.

5. Liu CM, Li YM, Semenov M, Han C, Baeg GH, Tan Y, Zhang ZH, Lin XH and He X.  (2002) Control of -catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.

6. Gottschalk I, Li YM and Lundahl P. (2000) Chromatography on cells: Analysis of solute interactions with the glucose transporter Glut 1 in human red cells adsorbed on lectin-gel beads. J Chromat B  Biomed Sci Appl. 739 (1) 55-62.

7. Li YM, Liao JL, Zhang R, Henriksson H and Hjerten S. (1999) Continuous beds for microchromatography: chromatogocusing and anion exchange chromatography. Anal Biochem. 267 (1): 121-124.

8. Li YM, Franklin G, Cui HM, Svensson K, He XB, Adam G, Ohlsson R and Pfeifer S. (1998) The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. J Biol Chem 273: 28247-28252.

9. Hjerten S, Ericson C, Li YM and Zhang R. (1998) Capillary electrophoresis and capillary chromatography. Theoretical analogies and practical differences. Biomed Chromatogr.12: 120-121.

10. Liao JL, Li YM and Hjerten S. (1996) Continuous beds for microchromatography: reversed phase chromatography. Anal Biochem. 234: 27-30.

11. Li YM, Brostedt P, Hjerten S, Nyberg F and Silberring J. (1995) Capillary LC-FAB MS using a high-resolving cation-exchanger, based on a continuous chromatographic matrix. Application to studies on neuropeptide peptidases. J Chromatogr B. 664: 426-430.

12. Li YM, Liao JL, Nakazato K, Mohammad J, Terenius L and Hjerten S. (1994) Continuous bed for microchromatography: cation-exchange chromatography. Anal Biochem. 223: 153-158.

13. Silberring J, Li YM, Nyberg F. and Hjerten S. (1993) Strategies in studies on neuropeptide processing by mass spectrometry. Biochem Soc Trans. 22: 136-140.

14. Mohammad J, Li YM, El-Ahman M, Nakazato K, Pettersson G and Hjerten S. 1993. Chiral-recognition chromatography of b-blockers on continuous polymer beds with immobilized cellulase as enantioselective protein. Chirality 5: 464-470.

15. Hjerten S, Li YM, Liao JL, Mohammad J, Nakazato K and Pettersson G. (1992) Continuous beds: high-resolving, cost-effective chromatographic matrices. Nature 356: 810-811.

16. Jiang JB and Li YM (1988) Sarcocystosis induced by Sarcocystis suihominis in China. In “Zoonoses in China” (Yu ES and Xu BK eds.) pp.888-891.

17. Li YM and Lian ZQ (1986) Studies on man-pig cyclic infection of Sarcocystis suihominis found in Yunnan Province, China. Acta Zoologica Sinica 32(4): 329-334.