SELF-INTRODUCTION：

Haocheng Lu is an assistant professor in School of Medicine, Southern University of Science and Technology. Haocheng completed his bachelor’s degree in clinical medicine at Peking University Health Science Center in 2014. In 2014-2019, Haocheng finished his PhD study at University of Michigan, Ann Arbor and continued his postdoc training from 2019 to 2022.

Haocheng’s work focuses on identifying new cardiovascular diseases-causal genes and develop novel treatments. The strategy includes human GWAS, next-generation sequencing and animal models. Haocheng also develops a in-vivo CRISPR screen platform to facilitate the discovery of new disease-associated genes.

EDUCATION:

Sep, 2008-June, 2014 Peking University Health Science Center, BS, Clinical Medicine

Sep, 2008-June, 2014 Peking University National School of Development, BS, Economics (double degree)

Aug, 2014-May 2019 University of Michigan, Ann Arbor, PhD, Molecular and Integrative Physiology

WOKRING EXPERIENCE:

May, 2019-Apr, 2022 University of Michigan Medical School, Postdoc

June, 2022-now, Southern University of Science and Technology, Assistant Professor

HONORS AND AWARDS:

American Heart Association, Predoctoral fellowship, 2016-2018

Young Investigator Award, Chinese American Academy of Cardiology, Chinese Society for Vascular Medicine, 2018

RESEARCH:

1.     Identify novel cardiovascular disease-causal genes with the integration of GWAS, multi-OMICS and animal models.

2.     Study macrophage function in disease with new in vivo CRIPSR screen method.

3.     Transform scientific discovery to clinical treatment.

MANUSCRIPT REVIEWER AND EDITOR：

Reviewer for Cardiovascular Drugs and Therapy， Journal of Molecular Histology， Frontiers in Immunology

PUBLICATIONS：

1.     Wang Z*, Lu H*, Garcia-Barrio M, Guo Y, Zhang J, Chen YE, Chang L. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022 Apr;178:106183.

2.     Lu H, Du W, Ren L, Hamblin MH, Becker RC, Chen YE, Fan Y. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. J Am Heart Assoc. 2021 Dec 21;10(24):e023601.

3.     Fan Y*, Wolford BN*, Lu H*, Liang W, Sun J, Zhou W, Rom O, Mahajan A, Surakka I, Graham SE, Liu Z, Kim H, Ramdas S, Fritsche LG, Nielsen JB, Gabrielsen ME, Hveem K, Yang D, Song J, Garcia-Barrio MT, Zhang J, Liu W, Zhang K, Willer CJ, Chen YE. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience. 2021 Nov 19;24(11):103196.

4.     Roychowdhury T*, Lu H*, Hornsby WE, Crone B, Wang GT, Guo DC, Sendamarai AK, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb GM, Patel HJ, Eliason J, Eagle KA, Yang B, Ganesh SK, Brumpton B, Åsvold BO, Skogholt AH, Hveem K, Pyarajan S, Klarin D, Tsao PS, Damrauer SM, Leal SM, Milewicz DM, Chen YE, Garcia-Barrio MT, Willer CJ. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021 Sep 2;108(9):1578-1589.

5.     Lu H, Zhang J, Chen YE, Garcia-Barrio MT. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021 Jun;35(3):637-654.

6.     Lu H, Sun J, Hamblin MH, Chen YE, Fan Y. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021 Jan;63:103207.

7.     Lu H, Sun J, Liang W, Chang Z, Rom O, Zhao Y, Zhao G, Xiong W, Wang H, Zhu T, Guo Y, Chang L, Garcia-Barrio MT, Zhang J, Chen YE, Fan Y. Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB. Circulation. 2020 Aug 4;142(5):483-498.

8.     Lu H, Sun J, Liang W, Zhang J, Rom O, Garcia-Barrio MT, Li S, Villacorta L, Schopfer FJ, Freeman BA, Chen YE, Fan Y. Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells. Physiol Genomics. 2019 Jun 1;51(6):224-233.

9.     Lu H, Fan Y, Qiao C, Liang W, Hu W, Zhu T, Zhang J, Chen YE. TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Sci Signal. 2017 Jan 31;10(464).