Faculty

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Gen-Qiang Chen
Research Associate Professor
2021 First prize of Shenzhen Natural Science
Research Associate Professor
chengq@sustech.edu.cn

Educational background:
2018.09—2021.06          PhD., Chemistry, Shanghai Institute of Organic Chemistry, CAS
2014.09—2018.06          B.S., Chemistry, Zhengzhou University

Work experience:

2021.06—present         Assosiate Professor, SUSTech
2018.07—2021.05         Assistant Professor, SUSTech


Honors and awards:
2021  First prize of Shenzhen Natural Science
2021 Shenzhen high-level talent introduction reserve level talent


Research Area:

Organic synthesis, Chiral ligands, Asymmetric catalysis, Asymmetric hydrogenation and so on. He mainly works on the design and synthesis of new chiral ligands and their application in asymmetric catalysis.


Publications:

[1] Zong, Y.; Zhang, R.; Ma, B.-D.; Peng, J.; Wu, C.; Zou, X.; Qian, Y.; Chen, G.-Q.*; Zhang, X.*, Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation. Sci. Adv. 2024, 10, eado9607.

[2] Xu, L.; Yang, T.; Sun, H.; Zeng, J.; Mu, S.; Zhang, X.; Chen, G.-Q.*, Rhodium-Catalyzed Asymmetric Hydrogenation and Transfer Hydrogenation of 1,3-Dipolar Nitrones. Angew. Chem., Int. Ed. 2024, 63, e202319662.

[3] Du, X.; Zhang, Y.; Yang, T.*; Xiao, Y.; He, J.; Chung, L. W.; Chen, G.-Q.*; Zhang, X.*, A versatile cobalt catalyst for highly enantioselective hydrogenation of carbonyl compounds. Chem Catal. 2024, 4, 100999.

[4] Wang, F.; Zhang, Z.; Chen, Y.; Ratovelomanana-Vidal, V.; Yu, P.*; Chen, G.-Q.*; Zhang, X.*, Stereodivergent Synthesis of Chiral Succinimides via Rh-Catalyzed Asymmetric Transfer Hydrogenation. Nat. Commun. 2022, 13, 7794.

[5] Wang, F.; Chen, Y.; Yu, P.8; Chen, G.-Q.*; Zhang, X., Asymmetric Hydrogenation of Oximes Synergistically Assisted by Lewis and Bronsted Acids. J. Am. Chem. Soc. 2022, 144, 17763-17768.

[6] Lin, B.; Yang, T.; Zhang, D.; Zhou, Y.; Wu, L.; Qiu, J.; Chen, G.-Q.*; Che, C.-M.*; Zhang, X.*, Gold-Catalyzed Desymmetric Lactonization of Alkynylmalonic Acids Enabled by Chiral Bifunctional P,N ligands. Angew. Chem., Int. Ed. 2022, 61, e202201739.

[7] Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.*; Lu, Y.; Zhang, X.*, Concise, scalable and enantioselective total synthesis of prostaglandins. Nat. Chem. 2021, 13, 692-697.

[8] Wang, F.; Yang, T.; Wu, T.; Zheng, L.-S.; Yin, C.; Shi, Y.; Ye, X.-Y.; Chen, G.-Q.*; Zhang, X.*, Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution. J. Am. Chem. Soc. 2021, 143, 2477-2483.

[9] Du, X.; Xiao, Y.; Yang, Y.; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.; Chen, G.-Q.*; Zhang, X.*, Enantioselective Hydrogenation of tetra-Substituted alpha,beta-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights. Angew. Chem., Int. Ed. 2021, 60, 11384-11390.

[10] Du, X.; Xiao, Y.; Huang, J.-M.; Zhang, Y.; Duan, Y.-N.; Wang, H.; Shi, C.; Chen, G.-Q.*; Zhang, X.*, Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids. Nat. Commun. 2020, 11, 3239.

[11] Chen, G.-Q.*; Huang, J.-M.; Lin, B.-J.; Shi, C.; Zhao, L.-Y.; Ma, B.-D.; Ding, X.-B.; Yin, Q.; Zhang, X.*, Highly Enantioselective Hydrogenation of tetra- and tri-Substituted Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands. CCS Chem. 2020, 2, 468-477.

[12] Chen, G.-Q.; Lin, B.-J.; Huang, J.-M.; Zhao, L.-Y.; Chen, Q.-S.; Jia, S.-P.; Yin, Q.; Zhang, X., Design and Synthesis of Chiral oxa-Spirocyclic Ligands for Ir-Catalyzed Direct Asymmetric Reduction of Bringmann's Lactones with Molecular H2. J. Am. Chem. Soc. 2018, 140, 8064-8068.

[13] Chen, G.-Q.; Zhang, X.-N.; Wei, Y.; Tang, X.-Y.; Shi, M., Catalyst-dependent divergent synthesis of pyrroles from 3-alkynyl imine derivatives: A noncarbonylative and carbonylative approach. Angew. Chem., Int. Ed. 2014, 53, 8492-8497.


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