SELF-INTRODUCTION：

Gangjian “GQ” Qin, MD, FAHA, is Chair Professor at Southern University of Science and Technology School of Medicine. Dr. Qin graduated from Tongji Medical University, Wuhan, and received Bachelor of Medicine (1981-1986) and Master of Medical Science (1986-1989). After served in the university affiliated Union Hospital as Pediatrician, Attending Physician and Lecturer for 6 years (1989-1995), he joined the International Centre for Genetic Engineering and Biotechnology, Italy (1995–1998) and subsequently University of Illinois at Chicago, USA (1998–2001) to complete his postdoctoral research training. Then, Dr. Qin served as Instructor in Medicine and Assistant Professor at St. Elizabeth Medical Center of Bostin, Tufts University (2001–2006); Assistant Professor and Associate Professor (with tenure award) at Northwestern University Feinberg School of Medicine (2007–2016); and tenured Professor, Vice Chair of Research for the Department of Biomedical Engineering, and Director of Molecular Cardiology at University of Alabama at Birmingham, School of Medicine and School of Engineering (2016–2022).

Dr. Qin’s research program is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. His laboratory discovered the roles of the E2F oncogenes in the ischemic angiogenesis and blood pressure regulation; identified a unique population of cardiac stem cells in the rodent heart; characterized the signaling mechanisms of SDF-1/CXCR4 axis in the maintenance of bone marrow stem cell niche; revealed the pivotal role of oxidative metabolism in the differentiation of endothelial progenitor cells; uncovered novel mechanisms of systemic response to ischemic cardiac injury through circulating extracellular vesicles; and recently, discovered the role of Sam68 in the regulation of glucose, lipid, and energy metabolism and in the pathogenesis of obesity and type-2 diabetes. Dr. Qin has published over 130 original research articles in major international journals, including Circulation, Circ Res, J Clin Invest, J Exp Med, PNAS, and Nat Comm. His research had been supported by the National Institute of Health (NIH), American Heart Association (AHA), and American Diabetes Association (ADA). In addition, Dr. Qin served on the editorial boards of multiple journals in stem cell biology and cardiovascular sciences including Circulation Research and on the review committees of national and international funding organizations including NIH, VA, and AHA. Dr. Qin also serves on the AHA Council on Basic Cardiovascular Science (BCVS) and Council on Cardiovascular Radiology and Intervention (CVRI). In the last 18 years, Dr. Qin has trained over 50 biomedical researchers and educators.

EDUCATION:

• 1981.09 –1981.07 Tongji Medical University, Pediatrics; Bachelor of Medicine

• 1986.09–1989.12 Tongji Medical University, Specialization in Neonatology; Master of Medical Science

WOKRING EXPERIENCE:

• 1989.12–1992.08 Resident; Union hospital of Tongji Medical University, Department of Pediatrics

• 1992.09–1995.10 Attending physician, Lecturer; Union hospital of Tongji Medical University, Department of Pediatrics

• 1995.10–1998.08 Postdoctoral Fellow; Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, Italy

• 1998.10–2001.04 Postdoctoral Fellow; Department of Medicine - Hematology/Oncology, University of Illinois at Chicago

• 2001.04–2004.08 Instructor in Medicine; Department of Medicine - Cardiovascular Medicine, St. Elizabeth Medical Center of Bostin, Tufts University

• 2004.09–2006.12 Assistant Professor; Department of Medicine - Cardiovascular Medicine, St. Elizabeth Medical Center of Bostin, Tufts University

• 2007.01–2012.08 Assistant Professor; Feinberg Cardiovascular Research Institute, Department of Medicine - Cardiology, Northwestern University Feinberg School of Medicine

• 2012.09–2016.06 Associate Professor (Tenured since 2013); Feinberg Cardiovascular Research Institute, Department of Medicine - Cardiology, Northwestern University Feinberg School of Medicine

• 2016.07–2022.09 Professor, Director of Molecular Cardiology, Vice Chair for Research (since Nov. 2017); Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine, School of Engineering

• 2022.09–present Chair Professor, Southern University of Science and Technology School of Medicine, Shenzhen, China

• HONORS AND AWARDS:

• 2004   Melvin Marcus Young Investigator Award in Cardiovascular Sciences (Finalist), American Heart Association

• 2007   Investigators Developing Excellence in Academics Award, Northwestern University Feinberg School of Medicine

• 2007   Searle Fellow for Teaching Excellence, Northwestern University

• 2010   Fellow of the American Heart Association (FAHA)

• 2018–2020   President, Academy of Cardiovascular Research Excellence

RESEARCH INTEREST:

1.     Ischemic injury, organ protection and repair

2.     Cardiac regeneration

3.     Stem cells and stem cell products

4.     Glucose, lipids, and energy metabolism

PUBLICATIONS：

Representative publications (from a total of 130)

1. Zentilin L.*, Qin G.*, Tafuro S., Dinauer M.C., Baum C., and Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Ther 2000 Jan; 7(2):153-66. doi: 10.1038/sj.gt.3301057. PMID: 10673720

2. Qin G., Takenaka T., Telsch K., Kelley L., Howard T., Levade T., Deans R., Howard B.H., Malech H.L., Brady R.O., and Medin J.A. Preselective gene therapy for Fabry disease. Proc Natl Acad Sci U S A 2001 Mar 13; 98(6):3428-33. doi: 10.1073/pnas.061020598. PMID: 11248095 PMCID: PMC30670

3. Yoon Y.S., Wecker A., Heyd L., Park J.S., Tkebuchava T., Kusano K., Hanley A., Scadova H., Qin G., Cha D.H., Johnson K.L., Aikawa R., Asahara T., and Losordo D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005 Feb 1; 115(2):326-38. doi: 10.1172/JCI22326 PMID: 15690083 PMCID: PMC546424

4. Kishore R., Qin G., Luedemann C., Bord E., Hanley A., Silver M., Gavin M., Yoon Y.S., Goukassian D., and Losordo D.W., The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 2005 Jun 16; 115(7):1785-96. doi: 10.1172/JCI22849 PMID: 15965500 PMCID: PMC1150283

5. Ii M., Nishimura H., Kusano K.F., Qin G., Yoon Y.S., Wecker A., Asahara T., and Losordo D.W., Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation 2005 Jul 5; 112(1):93-102. doi: 10.1161/CIRCULATIONAHA.104.511964 PMID: 15983249

6. Qin G., Ii M., Silver M., Wecker A., Bord E., Ma H., Gavin M., Goukassian D.A., Yoon Y.S., Papayannopoulou T., Asahara T., Kearney M., Thorne T., Curry C., Eaton L., Heyd L., Dinesh D., Kishore R., Zhu Y., and Losordo D.W., Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 2006 Jan 23; 203(1):153-63. DOI: 10.1084/jem.20050459. PMID: 16401693 PMCID: PMC2118065

7. Iwakura A., Shastry S., Luedemann C., Hamada H., Kawamoto A., Kishore R., Zhu Y., Qin G., Silver M., Thorne T., Eaton L., Masuda H., Asahara T., and Losordo D.W., Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006 Mar 28; 113(12):1605-14. doi: 10.1161/CIRCULATIONAHA.105.553925 PMID: 16534014

8. Qin G., Kishore R., Dolan C.M., Silver M., Wecker A., Luedemann C.N., Thorne T., Hanley A., Curry C., Heyd L., Dinesh D., Kearney M., Martelli F., Murayama T., Goukassian D.A., Zhu Y., and Losordo D.W., Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A 2006 Jul 18; 103(29):11015-20. doi: 10.1073/pnas.0509533103. PMID: 16835303 PMCID: PMC1544166

9. Hamada H., Kim M.K., Iwakura A., Ii M., Thorne T., Qin G., Asai J., Tsutsumi Y., Sekiguchi H., Silver M., Wecker A., Bord E., Zhu Y., Kishore R., and Losordo D.W., Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation 2006 Nov 21; 114(21):2261-70. doi: 10.1161/CIRCULATIONAHA.106.631465. PMID: 17088460

10. Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., and Losordo D.W., Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation 2007 Feb 13; 115(6):752-62. doi: 10.1161/CIRCULATIONAHA.106.647255. PMID: 17261656

11. Rajasingh J., Bord E., Hamada H., Lambers E., Qin G., Losordo D.W., and Kishore R., STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ Res 2007 Oct 26; 101(9):910-8. doi: 10.1161/CIRCRESAHA.107.156786. PMID: 17823373

12. Cho H.J., Lee N., Lee J.Y., Choi Y.J., Ii M., Wecker A., Jeong J.O., Curry C., Qin G., and Yoon Y.S., Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007 Dec 24; 204(13):3257-69. doi: 10.1084/jem.20070166. PMID: 18070934 PMCID: PMC2150988

13. Rajasingh J., Lambers E., Hamada H., Bord E., Thorne T., Goukassian I., Krishnamurthy P., Rosen K.M., Ahluwalia D., Zhu Y., Qin G., Losordo D.W., and Kishore R., Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res 2008 Jun 6; 102(11):e107-17. doi: 10.1161/CIRCRESAHA.108.176115. PMID: 18483406 PMCID: PMC2435186

14. Krishnamurthy P., Rajasingh J., Lambers E., Qin G., Losordo D.W., and Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 2009 Jan 30; 104(2):e9-18. doi: 10.1161/CIRCRESAHA.108.188243. PMID: 19096025 PMCID: PMC2774810

15. Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 2009 May 22; 104(10):1209-16 (Editorial commended). doi: 10.1161/CIRCRESAHA.109.197723. PMCID: PMC2756190

16. Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G., Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation 2009 Sep 29; 120(13):1213-21. doi: 10.1161/CIRCULATIONAHA.109.859207. PMCID: PMC2785027. (Editors pick)

17. Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang  Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G., CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 2010 Oct 29; 107(9):1083-93 doi: 10.1161/CIRCRESAHA.110.220970. PMID: 20847314 PMCID: PMC2966940 (Cover featured; Editors pick)

18. Sahoo S, Klyachko E, Thorne T, Misener S, Shinnick K, Millay M, Ito A, Liu T, Kamide C, Agarwal H, Perlman H, Qin G.,Kishore R, Losordo DW. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Circ Res 2011 Sep 16; 109(7):724-8. doi: 10.1161/CIRCRESAHA.111.253286. PMID: 21835908. PMCID: PMC3201702

19. Krishnamurthy P., Thal M., Verma S.K., Hoxha E., Lambers E., Ramirez V., Qin G., Losordo D.W., and Raj Kishore. IL-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res 2011 Nov 11; 109(11):1280-9. doi: 10.1161/CIRCRESAHA.111.248369. PMID: 21959218 PMCID: PMC3235675

20. Thal MA, Krishnamurthy P, Mackie AR, Hoxha E, Lambers E, Verma S, Ramirez V, Qin G, Losordo DW, Kishore R.  Enhanced Angiogenic and Cardiomyocyte Differentiation Capacity of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Augments their Efficacy for Ischemic Myocardial Repair. Circ Res 2012 Jul 6; 111(2):180-90. doi: 10.1161/CIRCRESAHA.112.270462. PMID: 22589373 PMCID: PMC3406600

21. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A, Kishore R. IL-10 Treatment Attenuates Pressure Overload-Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nulcear Factor-kB. Circulation 2012 Jul 24; 126(4):418-29. doi: 10.1161/CIRCULATIONAHA.112.112185. PMID: 22705886 PMCID: PMC3422741

22. Cheng M. and Qin G., Progenitor cell mobilization and recruitment: SDF-1, CXCR4, a4-integrin, and c-kit, Prog Mol Biol Transl Sci. 2012; 111:243-64. PMID: 22917234. DOI: 10.1016/B978-0-12-398459-3.00011-3 PMCID: PMC3556394 (Invited Review)

23. Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault M-A, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, MD, Losordo DW.  CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism. Circulation 2013 Jan 1; 127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. PMID: 23204107 PMCID: PMC3560409

24. Zhou J, Cheng M, Liao Y, Hu Y, Wu M, Wang Q, Qin B, Hong W, Zhu Y, Gao YM, Goukassian D, Zhao TC, Tang YL, Raj Kishore, Qin G. Rosuvastatin enhances angiogenesis via eNOS–dependent mobilization of endothelial progenitor cells PLoS ONE 2013 May 21; 8(5):e63126:1-7. doi: 10.1371/journal.pone.0063126. PMID: 23704894 PMCID: PMC3660394

25. Zhou J, Xu S, Cheng M, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in cardiac neovascularization PLoS ONE 2013 Jun 14; 8(6): e65755. doi:10.1371/journal.pone.0065755. PMID: 23799044 PMCID: PMC3683051

26. Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhou TC, Tang YL, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013 Jul; 60:68-71. doi: 10.1016/j.yjmcc.2013.04.009. PMID: 23603666 PMCID: PMC3684263

27. Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3-regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 2013 Oct 25; 113(10):1148-58. doi: 10.1161/CIRCRESAHA.113.301546. PMID: 24044950 PMCID: PMC4339272

28. Tongers J, Webber MJ, Vaughan EE, Sleep E, Renault M-A, Roncalli JG, Klyachko E, Thorne T, Yu Y, Marquardt K-T, Kamide CE, Ito A, Misener S, Millay M, Liu T, Jujo K, Qin G, Losordo DW, Stupp SI, Kishore R. Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix, J Mol Cell Cardiol 2014 Sep; 74:231-9. doi: 10.1016/j.yjmcc.2014.05.017. PMID: 25009075 PMCID: PMC4135436

29. Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res 2014 Dec 1; 104(3):412-22. doi: 10.1093/cvr/cvu222. PMID: 25341896. PMCID: PMC4296109

30. Cheng M, Huang K, Zhou J, Tang Y-L, Zhao TC, Miller RJ, Kishore R, Losordo DW, and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015 Apr; 81:49-53. doi: 10.1016/j.yjmcc.2015.01.024. PMID: 25655934 PMCID: PMC4380859

31. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015 Jun; 225:181-9. doi: 10.1530/JOE-14-0727. PMID: 25934704 PMCID: PMC4482239

32. Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VNS, Benedict C, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Qin G, Houser SR, Koch WJ, Kishore R. Embryonic Stem Cell-derived Exosomes promote Endogenous Repair Mechanisms and Enhance Cardiac Function following Myocardial Infarction. Circ Res 2015 Jun 19; 117(1):52-64 doi: 10.1161/CIRCRESAHA.117.305990. PMID: 25904597 PMCID: PMC4482130

33. Wang Y, Zhang L, Li Y, Chen L, Zhang X, Guo W, Zhang X, Qin G, He SH, Zimmerman A, Liu Y, Kim IM, Weintraub NL, Tang Y-L. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int’l J Cardiol 2015 Aug 1; 192:61-69. doi: 10.1016/j.ijcard.2015.05.020. PMID: 26000464 PMCID: PMC4469495

34. Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T. Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells 2016 Jun; 34(6):1487-500. doi: 10.1002/stem.2301. PMID: 26824887

35. Lizano P, Rashed E, Stoll S, Zhou N, Wen H, Hays TT, Qin G, Xie L-H, Depre C, Qiu H. The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo. Sci Rep 2017 Apr 20; 7:46324. doi: 10.1038/srep46324 PMID: 28425440 PMCID: PMC5397870

36. Arnone B, Chen JY, Qin G. Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivoderived cardiac progenitor cells. PLoS ONE  2017 Jun 22;12(6): e0180096. doi: 10.1371/journal.pone.0180096. PMID: 28640894 PMCID: PMC5481004

37. Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. Irisin Plays a Pivotal Role to Protect the Heart Against Ischemia and Reperfusion Injury. J Cell Physiol 2017 Dec; 232(12):3775-3785. doi: 10.1002/jcp.25857. PMID: 28181692 PMCID: PMC5550372

38. Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Dong N-G, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G. E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells. Circ Res 2018 Mar 2; 122(5):701-11. doi: 10.1161/CIRCRESAHA.117.311814. PMID: 29358228 PMCID: PMC6021021

39. Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, Hunter JD, Borovjagin AV, Walcott GP, Chen JY, Qin G, and Zhang J. Regenerative Potential of Neonatal Porcine Hearts. Circulation 2018 Dec 11; 138(24):2809-2816. doi: 10.1161/CIRCULATIONAHA.118.034886. PMID: 30030418. PMCID: PMC6301098

40. Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, and Qin G Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun 2019 Feb 27; 10(1):959 doi: 10.1038/s41467-019-08895-7. PMID: 30814518. PMCID: PMC6393447

41. Han S*, Xu Shiyue*, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Diyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P, Zhang C, Richard S, Qiu H, Zhang J, and Qin G. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol 2019 Dec; 137:82-92. doi: 10.1016/j.yjmcc.2019.10.003. PMID: 31639388 PMCID: PMC6889069

42. Berry JL, Zhu W, Tang Y, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang H-T, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res 2019 Jan 4; 124(1):161-169. PMID: 30605412. PMCID: PMC6350935 DOI: 10.1161/CIRCRESAHA.118.314216 (Invited Review)

43. Han D, Yang J, Zhang E, Liu Y, Boriboun C, Qiao A, Yu Y, Sun J, Xu S, Yang L, Yan W, Luo B, Lu D, Zhang C, Jie C, Mobley J, Zhang J, Qin G.. Analysis of mesenchymal stem cell proteome in situ in the infarcted heart. Theranostics 2020 Sep 14; 10(24):11324-38. doi: 10.7150/thno.47893. PMID: 33042285

44. Zhang E, Liu Y, Han C, Fan C, Wang L, Chen W, Du Y, Han D, Arnone B, Xu S, Wei Y, Mobley J, Qin G. Visualization and identification of bioorthogonally-labeled exosome proteins following systemic administration in mice. Front Cell Dev Biol 2021 Apr 7; 9:657456. doi: 10.3389/fcell.2021.657456. PMID: 33898459 PMCID: PMC8058422

45. Qiao A, Zhou J, Xu S, Ma W, Boriboun C, Kim T, Yan B, Deng J, Yang L, Zhang E, Song Y, Ma YC, Richard S, Zhang C, Qiu H, Habegger K, Zhang J, Qin G. Sam68 promotes hepatic gluconeogenesis via CRTC2. Nat Commun 2021 Jun 7; 12(1):3340. doi: 10.1038/s41467-021-23624-9. PMID: 34099657 PMCID: PMC8185084

46. Yang L, Deng J, Ma W, Qiao A, Xu S, Yu Y, Boriboun C, Kang X, Han D, Ernst P, Zhou L, Shi J, Zhang E, Li TS, Qiu H, Nakagawa S, Blackshaw S, Zhang J, Qin G. Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure. Theranostics 2021 Jul 6; 11(16):7995-8007. doi: 10.7150/thno.50990. PMID: 34335976 PMCID: PMC8315059

47. Qiao A, Ma W, Deng J, Zhou J, Han C, Zhang E, Boriboun C, Xu S, Zhang C, Jie C, Kim J, Habegger K, Qiu H, Zhao TC, Zhang J, Qin G. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure FASEB J 2021 Aug; 35(8):e21772. doi: 10.1096/fj.202100021R. PMID: 34252225 PMCID: PMC8285032

48. Sun X, Zhou N, Ma B, Wu W, Stoll S, Lai L, Qin G, and Qiu H. Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model. Cells 2021 Oct 26; 10(11):2891. doi: 10.3390/cells10112891. PMID: 34831118 PMCID: PMC8616236

49. Patil M, Saheera S, Dubey PK, Kahn-Krell A, Govindappa PK, Singh S, Tousif S, Zhang Q, Lal H, Zhang J, Qin G, Krishnamurthy P. Novel mechanisms of exosome-mediated phagocytosis of dead cells in injured heart. Circ Res 2021 Nov 12; 129(11):1006-1020. doi: 10.1161/CIRCRESAHA.120.317900. PMID: 34623174 PMCID: PMC8595793

50. Qiao A, Ma W, Jiang Y, Han C, Yan B, Zhou J, Qin G. Hepatic Sam68 regulates systemic glucose homeostasis and insulin sensitivity. Int’l J Mol Sci 2022; 23(19): doi: 10.3390/ijms231911469. PMID:36232770

51. Han C, Yang J, Sun J, and Qin G. Extracellular Vesicles in Cardiovascular Disease: Biological Functions and Therapeutic Implications. Pharmacol Ther 2022 May; 233:108025. doi: 10.1016/j.pharmthera.2021.108025. PMID: 34687770 (Invited Review)

52. Han C and Qin G. Reporter systems for assessments of extracellular vesicle transfer. Front Cardiovasc Med 2022 Jun 1;9:922420. doi: 10.3389/fcvm.2022.922420. PMID: 35722089 PMCID: PMC9198260

53. Han C, Yang J, Zhang E, Jiang Y, Qiao A, Du Y, Zhang Q, An J, Sun J, Wang M, Nguyen T, Lal H, Krishnamurthy P, Zhang J, Qin G. Metabolic labeling of cardiomyocyte-derived small extracellular-vesicle (sEV) miRNAs identifies miR-208a in cardiac regulation of lung gene expression. J Extracell Vesicles 2022 Oct;11(10):e12246. doi: 10.1002/jev2.12246. PMID: 36250966 PMCID: PMC9575700