SELF-INTRODUCTION：

Dr Cao is an associate professor at Southern University of Science and Technology, School of Medicine. He received his B.S. degree and PhD degree from East China University of Science and Technology and Dalian Institute of Chemical Physics, respectively. He then did his postdoc training at The Scripps Research Institute and Johns Hopkins University. He has published 18 papers, including Cell, Cancer Cell, Cell Host & Microbe, Nature Communications, Nature Protocols, Science Translational Medicine, Cell Reports. Among, 9 papers are first-author publications, including Cell (1 paper), Nature Communications (3 papers), and Nature Protocols (1 paper). He joins Southern University of Science and Technology, School of Medicine, as an independent PI from August 2022.

EDUCATION:

2005.09 – 2009.07, East China University of Science and Technology, B.S. degree

2009.09 – 2014.07, Dalian Institute of Chemical Physics, PhD degree

WOKRING EXPERIENCE:

2014.08 - 2019.01, The Scripps Research Institute, Postdoc

2019.02 - 2022.07, Johns Hopkins University, Postdoc

2022.08 - present, Southern University of Science and Technology, School of Medicine, Associate Professor

HONORS AND AWARDS:

Johns Hopkins University Department of Pathology Young Investigator Award, 2022

Scripps CHAVI-ID Young Investigator Award, 2018

Outstanding Doctoral Student Award of Yanchang Petroleum International Limited, 2014

RESEARCH:

Development of cutting-edge mass spectrometry methods and their applications in understanding of important biological questions as well as treatment of human diseases

PUBLICATIONS：

1. Liwei Cao*, Chen Huang*, Daniel Cui Zhou*, Yingwei Hu, T Mamie Lih, Sara R Savage, Karsten Krug, David J Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda V Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D Jewell, Galen Hostetter, Chelsea J Newton, Qing Kay Li, Michael H Roehrl, David Fenyö, Pei Wang, Alexey I Nesvizhskii, D R Mani, Gilbert S Omenn, Emily S Boja, Mehdi Mesri, Ana I Robles, Henry Rodriguez, Oliver F Bathe, Daniel W Chan, Ralph H Hruban, Li Ding, Bing Zhang, Hui Zhang, Clinical Proteomic Tumor Analysis Consortium. (2021) Proteogenomic Characterization of Pancreatic Ductal Adenocarcinoma. Cell, 184(19): 5031-5052. *: Co-first author.

2.  Liwei Cao*, T Mamie Lih*, Yingwei Hu, Michael Schnaubelt, Shao-Yung Chen, Yangying Zhou, Chuanyu Guo, Mingming Dong, Weiming Yang, Rodrigo Vargas Eguez, Lijun Chen, David J Clark, Akrit Sodhi, Qing Kay Li, Hui Zhang. (2022) Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis. Nature Communications, 13: 3910. *: Co-first author.

3. Liwei Cao, Jolene K Diedrich, Yuanhui Ma, Nianshuang Wang, Matthias Pauthner, Sung-Kyu Robin Park, Claire M Delahunty, Jason S McLellan, Dennis R Burton, John R Yates, James C Paulson. (2018) Global site-specific analysis of glycoprotein N-glycan processing. Nature Protocols, 13(6): 1196-1212.

4. Liwei Cao*, Matthias Pauthner*, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M Delahunty, Lin He, Javier Guenaga, Richard T Wyatt, William R Schief, Andrew B Ward, John R Yates, Dennis R Burton, James C Paulson. (2018) Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. Nature Communications, 9(1): 3693. *: Co-first author.

5. Liwei Cao, Jolene K Diedrich, Daniel W Kulp, Matthias Pauthner, Lin He, Sung-Kyu Robin Park, Devin Sok, Ching Yao Su, Claire M Delahunty, Sergey Menis, Raiees Andrabi, Javier Guenaga, Erik Georgeson, Michael Kubitz, Yumiko Adachi, Dennis R Burton, William R Schief, John R Yates III, James C Paulson. (2017) Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. Nature Communications, 8: 14954.

6. Liwei Cao, Long Yu, Zhimou Guo, Aijin Shen, Yunü Guo, Xinmiao Liang. (2014) N-Glycosylation site analysis of proteins from Saccharomyces cerevisiae by using hydrophilic interaction liquid chromatography-based enrichment, parallel deglycosylation, and mass spectrometry. Journal of Proteome Research, 13(3): 1485-93.

7. Liwei Cao*, Ye Zhang*, Linlin Chen, Aijin Shen, Xingwang Zhang, Shifang Ren, Jianxin Gu, Long Yu and Xinmiao Liang. (2014) Sample preparation for mass spectrometric analysis of human serum N-glycans using hydrophilic interaction chromatography-based solid phase extraction. Analyst, 139: 4538-4546. *: Co-first author.

8. Liwei Cao, Long Yu, Zhimou Guo, Xiuling Li, Xinya Xue, and Xinmiao Liang. (2013) Application of a strong anion exchange material in electrostatic repulsion-hydrophilic interaction chromatography for selective enrichment of glycopeptides. Journal of Chromatography A, 1299: 18-24.

9. Liwei Cao, Danhua Yu, Xinliang Wang, Yanxiong Ke, Yu Jin , Xinmiao Liang. (2011) The development of an evaluation method for capture columns used in two-dimensional liquid chromatography. Analytica Chimica Acta, 706: 184-190.

10. Chen Huang, Lijun Chen, Sara R Savage, Rodrigo Vargas Eguez, Yongchao Dou, Yize Li, Felipe da Veiga Leprevost, Eric J Jaehnig, Jonathan T Lei, Bo Wen, Michael Schnaubelt, Karsten Krug, Xiaoyu Song, Marcin Cieślik, Hui-Yin Chang, Matthew A Wyczalkowski, Kai Li, Antonio Colaprico, Qing Kay Li, David J Clark, Yingwei Hu, Liwei Cao, Jianbo Pan, Yuefan Wang, Kyung-Cho Cho, Zhiao Shi, Yuxing Liao, Wen Jiang, Meenakshi Anurag, Jiayi Ji, Seungyeul Yoo, Daniel Cui Zhou, Wen-Wei Liang, Michael Wendl, Pankaj Vats, Steven A Carr, D R Mani, Zhen Zhang, Jiang Qian, Xi S Chen, Alexander R Pico, Pei Wang, Arul M Chinnaiyan, Karen A Ketchum, Christopher R Kinsinger, Ana I Robles, Eunkyung An, Tara Hiltke, Mehdi Mesri, Mathangi Thiagarajan, Alissa M Weaver, Andrew G Sikora, Jan Lubiński, Małgorzata Wierzbicka, Maciej Wiznerowicz, Shankha Satpathy, Michael A Gillette, George Miles, Matthew J Ellis, Gilbert S Omenn, Henry Rodriguez, Emily S Boja, Saravana M Dhanasekaran, Li Ding, Alexey I Nesvizhskii, Adel K El-Naggar, Daniel W Chan, Hui Zhang, Bing Zhang, Clinical Proteomic Tumor Analysis Consortium. (2021) Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell, 39(3):361-379.

11. Andrew J Thompson, Liwei Cao, Yuanhui Ma, Xiaoning Wang, Jolene K Diedrich, Chika Kikuchi, Shelby Willis, Charli Worth, Ryan McBride, John R Yates, James C Paulson. (2020) Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins. Cell Host Microbe, 27(5): 725-735.

12. Kimmo Rantalainen, Zachary T Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion, Jonathan L Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, Elise Landais, James C Paulson, Ian A Wilson, Andrew B Ward. (2018) Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Reports, 23(11): 3249-3261.

13. Colin Havenar-Daughton, Anita Sarkar, Daniel W Kulp, Laura Toy, Xiaozhen Hu, Isaiah Deresa, Oleksandr Kalyuzhniy, Kirti Kaushik, Amit A Upadhyay, Sergey Menis, Elise Landais, Liwei Cao, Jolene K Diedrich, Sonu Kumar, Torben Schiffner, Samantha M Reiss, Grégory Seumois, John R Yates, James C Paulson, Steven E Bosinger, Ian A Wilson, William R Schief, Shane Crotty. (2018) The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Science Translational Medicine, 10(448): eaat0381.

14. Aijin Shen, Zhimou Guo, Long Yu, Liwei Cao and Xinmiao Liang. (2011) A novel zwitterionic HILIC stationary phase based on “thiol-ene” click chemistry between cysteine and vinyl silica. Chemical Communications, 47: 4550-4552.

15. Chitra Upadhyay, Roya Feyznezhad, Liwei Cao, Kun-Wei Chan, Kevin Liu, Weiming Yang, Hui Zhang, Jason Yolitz, James Arthos, Arthur Nadas, Xiang-Peng Kong, Susan Zolla-Pazner, Catarina E. Hioe. (2020) Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes. PLOS Pathogens, 16(12): e1009185.

16. Yangying Zhou, T. Mamie Lih, Jianbo Pan, Naseruddin Höti, Mingming Dong, Liwei Cao, Yingwei Hu, Kyung-Cho Cho, Shao-Yung Chen, Rodrigo Vargas Eguez, Edward Gabrielson, Daniel W. Chan, Hui Zhang, Qing Kay Li. (2020) Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. Journal of Hematology & Oncology, 13: 170.